Dapsone is a drug primarily used for the treatment of Hansen's disease, and it has also been employed in cases of bullous lupus erythematosus and some types of cutaneous vasculitis. Recently, its efficacy in the treatment of cutaneous lesions in dermatomyositis has been observed. We present two cases of dermatomyositis, amyopathic form, which were refractory to habitual treatment, but had an excellent response to dapsone therapy. 1,2 For half a century, dapsone has been used for its anti-inflammatory properties, particularly aimed at leukocytes, for the treatment of Hansen's Disease and autoimmune diseases, such as bullous lupus erythematosus and relapsing polychondritis. Literature has shown some reports of DM with good response of its cutaneous manifestations to the use of dapsone. We hereby present two patients with refractory amyopathic dermatomyositis, who responded to treatment with dapsone. Case 1Fifty five-year-old white male patient, who presented, four years ago, erythematous pruritic cutaneous eruptions, with the finding of photosensitivity in the face and upper trunk, shawl Sign and V-Sign on physical examination, besides heliotrope and Gottron's Sign. Muscle strength was preserved (degree: 5+/5+). Histopathological study of the skin revealed an epidermis with discrete acanthosis, edematous dermis with mononuclear infiltrate surrounding vessels and annexes, besides decrease of pillous follicles. Antinuclear factor (ANF) was negative, and Creatinophosphokinase (CPK) values were within normal range. No muscle biopsies or electroneuromyography (ENMG) were carried out. The case was diagnosed as amyopathic dermatomyositis, and treatment with chloroquine diphosphate at 250 mg/day was begun, without satisfactory response. Dapsone at 50 mg/day was then introduced and after two months the dose was built up to 100 mg/day, with a significant improvement. Later on, patient had the onset of an insidious ventilatory-dependent thoracic pain associated with weight loss, with the finding, on tomographic investigation, of a pulmonary nodule, the histopatho-