Low-grade gliomas are a heterogeneous group of neoplasms usually encountered in younger patient populations. These tumors represent a unique challenge because most patients will survive a decade or more and may be at a higher risk for treatment-related complications. Clinical observations over the years have identified a subset of low-grade gliomas that tends to manifest more aggressive clinical behavior and require earlier, more aggressive intervention. Clinical and molecular parameters may allow better assessment of prognosis and application of risk-adjusted management strategies that may include resection, radiation, or chemotherapy. Improved methods of long-term cognitive and functional assessment are desperately needed in this patient population.

Neurologic complications of non-Hodgkin's lymphoma represent challenging diagnostic and therapeutic issues. Leptomeningeal, epidural, and brain metastases are the most common neurologic complications, and each is associated with a poor prognosis. However, early recognition and intervention often result in improved quality of life and, for a subset of patients, an opportunity for longer survival.