Dermal filler-based enhancement of the jawline has become a popular method of non-surgical facial rejuvenation. This relatively novel application of fillers has the ability to camouflage the early senescence of the lower face caused by bony erosion, soft tissue ptosis, and volumetric changes in the periphery of the cervico-mandibular region. In this article, the authors review the age-related shifts that contribute to the loss of youthfulness of the lower face and outline the relevant neurovascular anatomy, regional aesthetic analysis and proper patient selection criteria that govern the successful delivery of high-quality results in this novel application of dermal fillers.