BACKGROUNDCarcinoma of breast has clinical heterogeneity with high morbidity and mortality. Determination of prognostic factors is important in improving the overall survival in breast cancer patients. HER2/neu is one of the powerful predictors of poor prognosis. Thus, a study of HER2/neu expression estimated by immunohistochemistry in breast cancer is the need of the hour. This study investigates correlations between the presence of HER2/neu and various clinicopathological prognostic parameters in primary breast carcinomas. 1. Study of the HER2/neu status in breast carcinomas in the study sample. 2. To find the association of HER2/neu status with clinicopathological prognostic parameters in breast carcinomas in the study sample. 3. To find the association of HER2/neu status with lymph node status.