Background Atrial fibrillation (AF) is the most common arrhythmia with a growing prevalence worldwide, especially in the elderly population. Patients with AF are at higher risk of serious life-threatening events and complications that may lead to long-term sequelae and reduce quality of life. The aim of our study was to examine the association of additional risk factors and comorbid medical conditions with AF in patients 65 years, or older. Methods We performed a retrospective electronic medical record review of patients aged 65 years and older, who visited our internal medicine office between July 1, 2020 and June 30, 2021. Results Among 2,433 patients, 418 patients (17.2%) had AF. Our analysis showed that for each unit increased in age, there was a 4.5% increase in the odds of AF (95% confidence interval (CI) 2.2-6.9%; P < 0.001). Compared to patients of Caucasian descent, African-American patients had significantly decreased odds of AF (odds ratio (OR) 0.274, 95% CI 0.141 - 0.531; P < 0.001). Patients with hypertension had 2.241 greater odds of AF (95% CI 1.421 - 3.534; P = 0.001). Additional comorbidities with significantly greater odds of AF included other cardiac arrhythmias (OR 2.523, 95% CI 1.720 - 3.720; P < 0.001), congestive heart failure (OR 3.111, 95% CI 1.674 - 5.784; P < 0.001), osteoarthritis (OR 3.014, 95% CI 2.138 - 4.247; P < 0.001), liver disease (OR 2.129, 95% CI 1.164 - 3.893; P = 0.014), and colorectal disease (OR 1.500 95% CI 1.003 - 2.243; P = 0.048). Comorbidities with significantly decreased odds of AF included other rheumatological disorder (OR 0.144, 95% CI 0.086 - 0.243; P < 0.001), non-steroidal anti-inflammatory drugs (NSAIDs) use (OR 0.206, 95% CI 0.125 - 0.338; P < 0.001), and corticosteroid use (OR 0.553, 95% CI 0.374 - 0.819; P = 0.003). Conclusions Increasing age, hypertension, presence of other cardiac arrhythmias, congestive heart failure, osteoarthritis, liver disease, and colorectal disease are associated with increased odds of having AF.

Introduction: Malignant neoplasms of the limb bones are rare. To our knowledge, there are few studies that analyze characteristics of these patients and reasons why they present to an emergency department (ED). Methods: We utilized the 2006-2012 Nationwide Emergency Department Sample to characterize primary diagnoses and outcomes of limb bone cancer patients presenting to an ED. Multivariate logistic regression was used to identify factors associated with high chance of inpatient admission. A p-value ≤0.05 was significant. Results: In this period, 4,020 limb bone cancer patients presented to the ED. Most patients were between ages of 18 and 29 (30.3%), male (58.1%), covered by private insurance (35.5%), in the second income quartile (26.3%), living in the South (35.3%), presenting to non-trauma hospitals (42.3%), and presenting to metropolitan teaching hospitals (53.0%). Most patients were admitted (64.9%) or discharged (29.1%). Most common primary diagnoses of the ED visit were white blood cell (WBC) disorders (8.6%), secondary malignancies (7.4%), pathologic disorder (5.9%), septicemia (4.8%), and central nervous system disorders (3.7%). Primary diagnoses associated with highest risk of inpatient admission were WBC disorder (odds ratio (OR)=21.1, 95% confidence interval (CI)=7.1-63.2; p&lt;0.001), pneumonia (OR=13.2, 95%CI=1.5-118.5, p=0.022), secondary malignancy (OR=11.1, 95%CI=3.4-36.3, p&lt;0.001), pathological fracture (OR=5.2, 95%CI=2.3-11.7, p&lt;0.001), and complication due to previous surgery or medical treatment (OR=3.9, 95%CI=1.4-11.4, p=0.012). Table 1 lists risks of inpatient admission associated with the 20 most common primary diagnoses. Conclusion: Patients with limb bone cancers are young patients who present to the ED with WBC disorders, secondary malignancies, pathologic bone fractures, and infections. Clinicians should keep these conditions in mind when treating these patients. Risk of Inpatient Admission Based on Primary Diagnosis in the Emergency Department Primary Diagnosis Odds Ratio (95% Confidence Interval) p-value White Blood Cell Disorder 21.1 (7.1-63.2) &lt;0.001 Pneumonia 13.2 (1.5-118.5) 0.022 Secondary Malignancy 11.1 (3.4-36.3) &lt;0.001 Pathologic Fracture 5.2 (2.3-11.7) &lt;0.001 Complication of Surgery or Medical Treatment 3.9 (1.36-11.4) 0.012 Complication of Device or Graft 3.8 (1.65-8.6) 0.002 Urinary Tract Infection 3.3 (1.14-9.6) 0.027 Anemia 3.0 (1.19-7.6) 0.020 Pleurisy or Pneumothorax 1.61 (0.33-7.8) 0.554 Arrhythmia 1.46 (0.39-5.5) 0.575 Skin Infection 1.13 (0.4-3.6) 0.829 Nervous System Disorder 1.10 (0.5-2.5) 0.826 Nausea or Vomiting 0.92 (0.32-2.6) 0.869 Fluid or Electrolyte Disorder 0.57 (0.14-2.3) 0.438 Fever 0.43 (0.15-1.19) 0.102 Chest Pain 0.23 (0.06-0.84 0.026 Connective Tissue Damage 0.11 (0.03-0.41) 0.001 Joint Disorder 0.10 (0.02-0.46) 0.003 Septicemia Not Available: All Admitted - Respiratory Failure Not Available: All Admitted - Citation Format: Lauren C. Ladehoff, Kamil Taneja, Karan Patel, Jeeyong Shin, Sahas Chandragiri, Hailey Hsiung, Michael Diaz, Eric M. Toloza. Analysis of emergency department patients with known limb bone malignancies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3215.

Introduction: In the US, 78,000 new melanoma cases are diagnosed every year. Melanoma patients often present to the emergency department (ED). However, few studies have identified the common reasons for these patients to present to the ED. Methods: We utilized the 2006-2012 Nationwide Emergency Department Sample to identify the most common primary diagnoses for ED visits by melanoma patients. Multi-variable logistic regression was used to identify characteristics that were associated with higher chance of inpatient admission. A p-value &lt;0.05 was considered significant. Results: Between 2006 and 2012, 239,956 melanoma patients presented to the ED. Most patients were ≥70 years old (50.7%), male (53.6%), Medicare beneficiaries (60.5%), of the highest income quartile (31.5%), living in the South (35.5%), presenting to non-trauma hospitals (49.6%), and presenting to metropolitan non-teaching hospitals (45.3%). Most patients (57.6%) were admitted. Common primary diagnoses for melanoma patients in the ED were secondary malignancy (5.3%), chest pain (4.8%), cardiac arrhythmia (3.3%), pneumonia (3.1%), and complications related to a prior surgery or medical treatment (2.7%). Primary diagnoses associated with the highest risk of inpatient admission were septicemia (odds ratio [OR]=29.2, 95% confidence interval (CI)=19.2-44.5; p&lt;0.001), secondary malignancy (OR=16.5, 95%CI=13.4-20.2; p&lt;0.001), and acute cerebrovascular disease (OR=4.6, 95%CI=3.7-5.8; p&lt;0.001). The primary diagnoses associated with the lowest risk of inpatient admission were contusion (OR=0.09, 95%CI=0.07-0.11; p&lt;0.001), abdominal pain (OR=0.18, 95%CI=0.15-0.22; p&lt;0.001), and lower respiratory disease (OR=0.21, 95%CI=0.17-0.25; p&lt;0.001). Table 1 lists the 20 most common primary diagnoses associated with risk of admission. Conclusion: Melanoma patients frequently present to the ED for many reasons, with septicemia and a secondary malignancy being the most common diagnoses for inpatient admission. Risk of Inpatient Admission Based on Primary Diagnosis in the Emergency Room for Melanoma Patients Primary Diagnosis in the ED Odds Ratio (95% Confidence Interval) p-value Septicemia 29.2 (19.2-44.6) &lt;0.001 Secondary Malignancy 16.5 (13.4-20.2) &lt;0.001 Pneumonia 4.60 (3.86-5.47) &lt;0.001 Acute Cerebrovascular Disease 4.60 (3.68-5.77 &lt;0.001 Congestive Heart Failure 3.06 (2.50-3.81) &lt;0.001 Coronary Artery Disease 2.95 (2.28-3.82) &lt;0.001 Arrhythmia 1.82 (1.60-2.07) &lt;0.001 Fluid or Electrolyte Disorder 1.68 (1.41-2.01) &lt;0.001 Skin Infection 1.33 (1.16-1.51) &lt;0.001 Complicaiton of Prior Surgery or Medical Treatment 1.23 (1.07-1.43) 0.005 Chronic Obstructive Pulmonary Disease 1.12 (0.97-1.30) 0.128 Urinary Tract Infection 0.98 (0.85-1.12) 0.741 Myocardial Infarction 0.96 (0.88-1.05) 0.376 Nervous System Disorder 0.75 (0.63-0.89) 0.001 Syncope 0.69 (0.59-0.81) &lt;0.001 Chest Pain 0.32 (0.29-0.37) &lt;0.001 Spondylosis 0.28 (0.24-0.34) &lt;0.001 Lower Respiratory Disease 0.21 (0.17-0.25) &lt;0.001 Abdominal Pain 0.18 (0.15-0.22) &lt;0.001 Contusion 0.09 (0.07-0.11) &lt;0.001 Citation Format: Henna Hundal, Kamil Taneja, Karan Patel, James E. Siegler, Jesse Thon, Jeeyong Shin, Hailey Hsiung, Michael Diaz, Eric M. Toloza. Melanoma patients in the emergency department: Characteristics and outcomes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3220.