Phytophthora root and stem rot caused by P. sojae is a destructive soybean soil-borne disease found worldwide. Discovery of genes conferring broad-spectrum resistance to the pathogen is a need to prevent the outbreak of the disease. Here, we show that soybean Rps11 is a 27.7-kb nucleotide-binding site-leucine-rich repeat (NBS-LRR or NLR) gene conferring broad-spectrum resistance to the pathogen. Rps11 is located in a genomic region harboring a cluster of large NLR genes of a single origin in soybean, and is derived from rounds of unequal recombination. Such events result in promoter fusion and LRR expansion that may contribute to the broad resistance spectrum. The NLR gene cluster exhibits drastic structural diversification among phylogenetically representative varieties, including gene copy number variation ranging from five to 23 copies, and absence of allelic copies of Rps11 in any of the non-Rps11-donor varieties examined, exemplifying innovative evolution of NLR genes and NLR gene clusters.

We suggest that the Virgo Overdensity (VOD) of stars in the stellar halo is the result of a radial dwarf galaxy merger that we call the Virgo Radial Merger. Because the dwarf galaxy passed very near to the Galactic center, the debris has a large range of energies but nearly zero L z angular momentum. The debris appears to extend from 5 to 50 kpc from the Sun in the Virgo region. We connect different parts of this merger debris to the Perpendicular and Parallel Streams (the Virgo Stellar Stream is associated with either or both of these streams), the Hercules-Aquila Cloud (HAC), and possibly the Eridanus Phoenix Overdensity (EriPhe). This radial merger can explain the majority of the observed moving groups of RR Lyrae and blue horizontal branch stars that have previously been identified in Virgo. This merger also produces debris in the Solar neighborhood similar to that identified as the Gaia-Enceladus or Gaia-sausage merger. Orbits are provided for components of the Virgo Radial Merger progenitor and for debris that appears to be related to the Cocytos Stream, which was also recovered in the Virgo region.

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