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The Pulse Physiology Platform is an open-source software application designed to enable accurate and consistent, real-time physiologic simulations for improved medical training and clinical decision-making tools. The platform includes a physiology engine comprised of well-validated lumped-parameter models, differential equations representing feedback mechanisms, and a pharmacokinetic/pharmacodynamic model. The platform also includes a common data model for standard model and data definitions and a common software interface for engine control and robust physics-based circuit and transport solvers. The Pulse Platform has been incorporated into a number of commercial, research, and academic tools for medical simulation. Significance: The Pulse Platform is an innovative, well-validated, open-source tool for medical modeling and simulation in the training and clinical decision-making field.

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