The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.

The objective of this paper is to provide an overview of the present status and procedures related to surface precipitation observations at Environment and Climate Change Canada (ECCC). This work was done to support the ongoing renewal of observation systems and networks at the Meteorological Service of Canada. The paper focusses on selected parameters, namely, accumulated precipitation, precipitation intensity, precipitation type, rainfall, snowfall, and radar reflectivity. Application-specific user needs and requirements are defined and captured by World Meteorological Organization (WMO) Expert Teams at the international level by Observing Systems Capability Analysis and Review (OSCAR) and WMO Integrated Global Observing System (WIGOS), and by ECCC user engagement initiatives within the Canadian context. The precipitation-related networks of ECCC are separated into those containing automatic instruments, those with human (manual) observers, and the radar network. The unique characteristics and data flow for each of these networks, the instrument and installation characteristics, processing steps, and limitations from observation to data distribution and storage are provided. A summary of precipitation instrument-dependent algorithms that are used in ECCC's Data Management System is provided. One outcome of the analysis is the identification of gaps in spatial coverage and data quality that are required to meet user needs. Increased availability of data, including from long-serving manual sites, and an increase in the availability of precipitation type and snowfall amount are identified as improvements that would benefit many users. Other recognized improvements for in situ networks include standardized network procedures, instrument performance adjustments, and improved and sustained access to data and metadata from internal and external networks. Specific to radar, a number of items are recognized that can improve quantitative precipitation estimates. Increased coverage for the radar network and improved methods for assessing and portraying radar data quality would benefit precipitation users.

The suspended-load backpack is found to improve the energy efficiency of walking with a load in some scenarios. The objective of this study is to (i) analyze the dynamic load of the suspended-load backpack over a range of walking speeds and pack masses, and (ii) determine the optimal design parameters for the suspended-load backpack to minimize the effect of dynamic load on the efficiency of walking. A simple spring, damper and mass system is used to model the performance of the suspendedload backpack as well as the typical hiking pack. The oscillating load and phase angle are calculated over a range of loading and spring stiffness values to determine the system resonance and optimal spring stiffness design range for the suspended-load backpack. Our results reveal that the stiffness for the suspended-load backpack should be designed below one half of the resonance stiffness to minimize dynamic loads at a given walking speed. The location and magnitude of the maximum phase angle is also calculated. A performance comparison between the suspended-load backpack and a typical hiking pack demonstrates the beneficial range for the suspendedload backpack. The suspended-load backpack is found to provide significant reductions in the peak backpack load, compared with a typical hiking pack, while carrying large loads at fast walking speeds. The suspended-load backpack performs poorly for low pack loads due to in-phase oscillations between the pack and the walking person.

Accurate snowfall measurements are necessary for meteorology, hydrology, and climate research. Typical uses include creating and calibrating gridded precipitation products, the verification of model simulations, driving hydrologic models, input into aircraft deicing processes, and estimating streamflow runoff in the spring. These applications are significantly impacted by errors in solid precipitation measurements. The recent WMO Solid Precipitation Intercomparison Experiment (SPICE) attempted to characterize and reduce some of the measurement uncertainties through an international effort involving 15 countries utilizing over 20 types and models of precipitation gauges from various manufacturers. Key results from WMO-SPICE are presented herein. Recent work and future research opportunities that build on the results of WMO-SPICE are also highlighted.

Abstract. Collection efficiency transfer functions that compensate for wind-induced collection loss are presented and evaluated for unshielded precipitation gauges. Three novel transfer functions with wind speed and precipitation fall velocity dependence are developed, including a function from computational fluid dynamics modelling (CFD), an experimental fall velocity threshold function (HE1), and an experimental linear fall velocity dependence function (HE2). These functions are evaluated alongside universal (KUniversal) and climate-specific (KCARE) transfer functions with wind speed and temperature dependence. Transfer function performance is assessed using 30 min precipitation event accumulations reported by unshielded and shielded Geonor T-200B3 precipitation gauges over two winter seasons. The latter gauge was installed in a Double Fence Automated Reference (DFAR) configuration. Estimates of fall velocity were provided by the Precipitation Occurrence Sensor System (POSS). The CFD function reduced the RMSE (0.08 mm) relative to KUniversal (0.20 mm), KCARE (0.13 mm), and the unadjusted measurements (0.24 mm), with a bias error of 0.011 mm. The HE1 function provided a RMSE of 0.09 mm and bias error of 0.006 mm, capturing the collection efficiency trends for rain and snow well. The HE2 function better captured the overall collection efficiency, including mixed precipitation, resulting in a RMSE of 0.07 mm and bias error of 0.006 mm. These functions are assessed across solid and liquid hydrometeor types and for temperatures between −22 and 19 ∘C. The results demonstrate that transfer functions incorporating hydrometeor fall velocity can dramatically reduce the uncertainty of adjusted precipitation measurements relative to functions based on temperature.