Introduction/Objective. The objective of this paper was to determine the connection between the socioeconomic status (SES) of the respondents and smoking cigarettes, alcohol and marijuana use. Is there a connection between the SES respondents and their gender and place of residence? Methods. In a cross-sectional study based on The European School Survey Project on Alcohol and Other Drugs questionnaire (ESPAD), adapted to this research, a total of 4188 primary and secondary school respondents from Brcko District of Bosna and Herzegovina participated. The data was collected using questionnaire prepared for each respondent. Data on gender, marital status, occupation and professional qualifications of parents were used to determine a family's SES according to the Hollingshead methodology. Results. Alcohol and marijuana use are in relation to SES respondents (p < 0.001 or p = 0.008): respondents living in low-SES families use alcohol or marijuana at a lower percentage than respondents from middle-SES or high-SES families. Smoking habits are not in relation to SES respondents (p = 0.678). The place of residence is connected with SES respondents (p < 0.001): more respondents from low-SES families live in the rural areas, as those from medium-SES and high SES families who in the majority live in the urban. Conclusion. The SES of the respondents is in relation to the place of residence, alcohol and marijuana use, but it is not related to cigarette smoking