Malaria is a parasitic infectious disease that remains one of the focuses of world health problems. The ethanol extract of Hedyotis corymbosa has biochemical compounds potentially become a new antimalarial drug. This study aimed to analyze the effect of this extract on parasitemia and hepatomegaly in mice infected with Plasmodium berghei ANKA. Twentyfive BALB/c mice were infected with P. berghei ANKA and grouped into 5 groups. Group 1-3 were treated with 250 mg/Kg BW (HC250), 300 mg/Kg BW (HC300), and 350 mg/Kg BW (HC350) of ethanol extract of H. corymbosa (EEHC), respectively. Group 4 was a positive control (POS) which was given dihydroartemisisnin-piperaquin (DHP) and Group 5 was a negative control (NEG) which was only given CMC Na 1%. Treatments were given orally once a day for four consecutive days. Parasitemia was observed daily on Giemsa-stained tail blood smear. On day 5 the mice were sacrificed, blood were collected by cardiac punctured, the livers were removed and the length, width, and weight were measured. There was no significant difference on parasitemia between Group 1, 2, 3 and NEG. However, the highest inhibition of parasite s growth was found in Group 3 (61.4%. Observation on hepatomegaly, showed that a significant difference on the length of the liver was found between Group 3 and NEG.

Malaria is a disease transmitted by the bite of the female Anopheles mosquito and caused by protozoa of the genus Plasmodium. Malaria infection has several manifestations with cerebral malaria (CM) being the most severe neurological complication and a leading cause of malaria death. Cerebral malaria is characterized by a coma at least 1 hour after a seizure or a hypoglycemia, asexual forms of Plasmodium falciparum on peripheral blood smears, with the absence of any other causes of coma. This definition is quite vague in practice, thus making an accurate identification of clinical characteristics of cerebral malaria necessary in diagnosis to help reducing malaria deaths. This article is to summarize the medical literature to clarify the clinical characteristics of cerebral malaria.