Although allergies to antibiotics are commonly stated, allergies to cephalosporin antibiotics are uncommonly reported. Furthermore, dermatologic and systemic reactions from cephalosporin exposure involving end-organ damage are rare. We present a case of cephalexin, a cephalosporin, induced hypersensitivity vasculitis causing characteristic non-blanching purpuric lesions along with acute kidney failure necessitating hospitalization, corticosteroids, and initiation of hemodialysis.
Key indicators: single-crystal X-ray study; T = 298 K; mean (C-C) = 0.008 Å; R factor = 0.049; wR factor = 0.102; data-to-parameter ratio = 17.5.In the title compound, [Rh 2 (C 8 H 8 NO) 4 (C 8 H 7 N)], the four acetamidate ligands bridging the dirhodium core are arranged in a 2,2-trans manner. One Rh II atom is five-coordinate, in a distorted pyramidal geometry, while the other is six-coordinate, with a disorted octahedral geometry. For the six-coordinate Rh II atom, the axial nitrile ligand shows a non-linear Rhnitrile coordination with an Rh-N-C bond angle of 166.4 (4) and a nitrile N-C bond length of 1.138 (6) Å . Each unique Rh II atom is coordinated by a trans pair of N atoms and a trans pair of O atoms from the four acetamide ligands. The N eq -Rh-Rh-O eq torsion angles on the acetamide bridge varies between 12.55 (11) and 14.04 (8) .In the crystal, the 3-methylbenzonitrile ring shows ainteraction with an inversion-related equivalent [interplanar spacing = 3.360 (6) Å ]. A phenyl ring on one of the acetamide ligands also has a face-to-face -interaction with an inversion-related equivalent [interplanar spacing = 3.416 (5) Å ].
Related literatureFor the synthesis and structures of three related compounds, see Eagle et al. (2000Eagle et al. ( , 2012Eagle et al. ( , 2013.
Hemophagocytic lymphohistiocytosis (HLH) is a highly detrimental syndrome that can progress to multiorgan failure, necessitating the resources of an intensive care unit, with a mortality rate as high as 40%. Secondary HLH is usually triggered by infection, most often from a viral infection or malignancy. Management of HLH in adults is challenging as treatment algorithms targeting hyperinflammation are based on pediatric protocols, such as HLH-94 and HLH-2004. To our knowledge, there are only a few reported cases of HLH secondary to ehrlichiosis infection and none in elderly patients with multiple comorbidities. Here, we present a unique case of HLH secondary to ehrlichiosis infection in an 82-year-old female successfully treated with antibiotics and steroids.
This report aims to review a case of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) by comparing the patient's course with the current literature.
BIA-ALCL is a specific type of T-cell lymphoma that can develop after breast implantation, but has only recently been recognized within the last decade. Although overall rare, certain types of breast implants have increased association with developing subsequent lymphoma. This case occurred after mastectomy with breast reconstruction for unilateral invasive ductal carcinoma with a textured, saline Allergan breast implant. BIA-ALCL manifested and was symptomatic nine years after implantation.
The complex molecule of the title compound, [Rh 2 {N(C 6 H 5 )-COCH 3 } 4 (C 8 H 7 N) 2 ], exhibits inversion symmetry. The four acetamidate ligands bridging the dirhodium core are arranged in a 2,2-trans manner with two N atoms and two O atoms coordinating to each Rh II atom trans to one another. The N eq -Rh-Rh-O eq torsion angles on the acetamidate bridge vary between À4.07 (5) and À6.78 (7). The axial nitrile ligands complete the distorted octahedral coordination sphere of each Rh II atom and show a nonlinear coordination with Rh-N-C bond angles of 151.6 (3) and 152.5 (3). The bond lengths of the two nitrile triple bonds are 1.133 (5)
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