. (2006) 'The fusiform face area is not su cient for face recognition : evidence from a patient with dense prosopagnosia and no occipital face area.', Neuropsychologia., 44 (4). pp. 594-609. Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

PurposeRetinoblastoma is a rare eye cancer that generally occurs before 5 years of age and often results in enucleation (surgical removal) of the cancerous eye. In the present study, we sought to determine the consequences of early monocular enucleation on the morphological development of the anterior visual pathway including the optic chiasm and lateral geniculate nucleus.MethodsA group of adults who had one eye enucleated early in life due to retinoblastoma was compared to binocularly intact controls. Although structural changes have previously been reported in late enucleation, we also collected data from one late enucleated participant to compare to our early enucleated participants. Measurements of the optic nerves, optic chiasm, optic tracts and lateral geniculate nuclei were evaluated from T1 weighted and proton density weighted images collected from each participant.ResultsThe early monocular enucleation group exhibited overall degeneration of the anterior visual system compared to controls. Surprisingly, however, optic tract diameter and geniculate volume decreases were less severe contralateral to the remaining eye. Consistent with previous research, the late enucleated participant showed no asymmetry and significantly larger volume decreases in both geniculate nuclei compared to controls.ConclusionsThe novel finding of an asymmetry in morphology of the anterior visual system following long-term survival from early monocular enucleation indicates altered postnatal visual development. Possible mechanisms behind this altered development include recruitment of deafferented cells by crossing nasal fibres and/or geniculate cell retention via feedback from primary visual cortex. These data highlight the importance of balanced binocular input during postnatal maturation for typical anterior visual system morphology.

The study of brain-damaged patients and advancements in neuroimaging have lead to the discovery of discrete brain regions that process visual image categories, such as objects and scenes. However, how these visual image categories interact remains unclear. For example, is scene perception simply an extension of object perception, or can global scene "gist" be processed independently of its component objects? Specifically, when recognizing a scene such as an "office," does one need to first recognize its individual objects, such as the desk, chair, lamp, pens, and paper to build up the representation of an "office" scene? Here, we show that temporary interruption of object processing through repetitive TMS to the left lateral occipital cortex (LO), an area known to selectively process objects, impairs object categorization but surprisingly facilitates scene categorization. This result was replicated in a second experiment, which assessed the temporal dynamics of this disruption and facilitation. We further showed that repetitive TMS to left LO significantly disrupted object processing but facilitated scene processing when stimulation was administered during the first 180 msec of the task. This demonstrates that the visual system retains the ability to process scenes during disruption to object processing. Moreover, the facilitation of scene processing indicates disinhibition of areas involved in global scene processing, likely caused by disrupting inhibitory contributions from the LO. These findings indicate separate but interactive pathways for object and scene processing and further reveal a network of inhibitory connections between these visual brain regions.