No abstract

The optineurin gene and protein are evolutionary conserved between humans and the rhesus monkey. High similarity of ocular expression and tissue distribution between the two optineurin proteins suggests that this nonhuman primate is a suitable model for the pathophysiology and treatment of human glaucomatous optic neuropathy.

dedication D.J.C. I owe a debt of thanks to several colleagues for the help and patience that allowed me to have a part in this project. In particular, my appreciation to Mr. Mike Taschwer for putting his exceptional talents and hard work into the preparation of illustrations for this book; to the exceptional library staff at Covance, who generously and patiently answered our calls for research assistance; and to Dr. Bob Hall for his contribution in photography and clinical pathology. Last, but most importantly, thanks to my husband, Mark, for his endless and ongoing encouragement and support of my career. J.S. I would like to express my thanks to Steve Van Adestine for his patience and photography skills, along with Carolyn Dugan, who modeled for the pictures. My veterinary technicians went out of their way to assist in the shoot and, as always, provided phenomenal support for the entire process. I extend my appreciation for their expertise and attention to detail. Finally, my thanks to Dr. Mike Koch for advising me throughout the revision process.