No abstract

BACKGROUND & AIMS-Colorectal cancer (CRC) is uncommon in individuals <50 years old. Lynch Syndrome is caused by germline mutations in DNA mismatch repair (MMR) genes and associated with early-onset CRC, but little is known about the proportion of young patients with apparently sporadic CRC who actually have Lynch Syndrome. We examined patterns of microsatellite instability (MSI) and expression of MMR genes among patients <50 years old with non-familial CRC (patients with more than family member with CRC).

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