In the anti-human trafficking movement, multi-disciplinary teams have emerged as a best practice for collaborating and coordinating efforts in combating human trafficking. Many multi-disciplinary teams are comprised of federal, state and local partners representing law enforcement, prosecutors and service providers. The concept of sustaining the multi-disciplinary teams is a relatively new area of discussion in the anti-human trafficking movement. This paper explores the Greater New Orleans Human Trafficking Task Force sustainability process as an illustrative example to shed light on the issues that arose during the process for this Task Force, and which may be salient for other Task Forces. This retrospective presentation of the comments and observations made by the Greater New Orleans Human Trafficking Task Force members suggest emerging themes that may help to clarify the concepts other Task Forces should consider and to predict the sustainability outcomes. The members’ accounts incorporated in this article are presented as valid points of view for framing conclusions that may be applicable in other contexts and to further the conversation in this understudied area of sustainability. The key focal points related to sustainability explored in this conceptual paper include leadership, funding, collaboration, trust and relationship building, and change is constant.