Background Resuscitating patients with suspected or confirmed COVID-19 imposes unique challenges to organizations and code blue teams. Studies that applied the American Heart Association (AHA) COVID-19–related Interim Resuscitation Guideline and similar European guidelines are scarce. Objective This study aimed to develop and test a cardiopulmonary resuscitation protocol based on the AHA COVID-19–related Interim Resuscitation Guideline. Methods The study was conducted as an in situ simulation in a medical intensive care unit. The COVID-19 cardiopulmonary resuscitation protocol was created and validated by 11 health care team members and tested using 4 simulation sessions where 46 code blue team members participated. During the simulation, we observed role clarity, the effectiveness of communication, team dynamics, infection control measures, and the availability of essential supplies and equipment. Results The main issues identified in each simulation session were debriefed to the code blue teams and used to further revise the protocol. These include the assignment of tasks, availability of equipment and supplies, and failure of communication between the in-room and out-of-room teams. Solutions included changes in the placement of team members and roles and responsibilities; the creation of an isolation code medication package, a respiratory therapy kit, and an isolation code blue bag; and the use of two-way radios and N-95 masks with eye goggles to enhance communication between the teams. Conclusions This study shed light on the challenges to implement the AHA COVID-19–related Interim Resuscitation Guideline. The in situ simulation was an effective approach for rapid training, identifying unreliable equipment and ineffective and inefficient workflow, and managing the complexity of the physical environment.

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BACKGROUND Resuscitating patients with suspected or confirmed COVID-19 imposes unique challenges to organizations and code blue teams. Studies that applied the American Heart Association (AHA) COVID-19-related Interim Resuscitation Guideline and similar European guidelines are scarce. OBJECTIVE This study aimed to develop and test a cardiopulmonary resuscitation (CPR) protocol based on the AHA COVID-19-related Interim Resuscitation Guideline. METHODS The study was conducted as an in-situ simulation in a medical intensive care unit. The COVID-19 CPR protocol was created and validated by 11 healthcare team members and was tested using four simulation sessions where 46 code blue team members participated. During the simulation, we observed role clarity, effectiveness of the communication, team dynamics, infection control measures, and availability of essential supplies and equipment. RESULTS The main issues identified in each simulation session were debriefed to the code blue teams and were used to further revise the protocol. These include assignment of tasks, availability of equipment and supplies, and failure of communication between the in-room and out-of-room teams. Solutions included changes in placement of team members and roles and responsibilities; creation of isolation code medication package, a respiratory therapy kit, and isolation code blue bag; and utilization of two-way radios and N-95 with eye goggles to enhance the communication between the teams. CONCLUSIONS The study shed the light on challenges to implement the AHA COVID-19-related Interim Resuscitation Guideline. The in-situ simulation was an effective approach for rapid training and identifying unreliable equipment, ineffective and inefficient workflow, and managing the complexity of the physical environment.