Running headAnterior 180˚ versus Nissen fundoplication for GERD: a meta-analysis Word count 3161Archived at the Flinders Academic Commons: http://dspace.flinders.edu.au/dspace/ 2 Mini-AbstractSystematic review and meta-analysis demonstrating that laparoscopic anterior 180˚ fundoplication (180˚ LAF) reduces short and longer-term dysphagia and gas-related symptoms compared to laparoscopic Nissen fundoplication, with similar reflux control, dilatations and reoperation rate. These results lend level 1a support for the use of 180˚ LAF for the surgical treatment of GERD.Archived at the Flinders Academic Commons: http://dspace.flinders.edu.au/dspace/ 3 Structured abstractObjective: To compare short and longer-term outcome after laparoscopic anterior 180˚ fundoplication (180˚ LAF) versus laparoscopic Nissen fundoplication (LNF). Summary of background data:LNF is currently the most frequently performed surgical therapy for GORD. Alternatively, 180˚ LAF has been alleged to reduce troublesome dysphagia and gas-related symptoms, with similar reflux control. Methods Conclusions:At one and five years, dysphagia and gas-related symptoms are lower after 180˚ LAF compared with LNF, and esophageal acid exposure and esophagitis are similar, with no differences in heartburn scores, patient satisfaction, dilatations and reoperation rate.These results lend level 1a support for the use of 180˚ LAF for the surgical treatment of GERD.

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Survivors after CRS and HIPEC have postoperative quality of life similar to preoperatively, with most of the reduced elements recovering after 6-12 months. We conclude that reduced quality of life of patients after CRS and HIPEC should not be used as an argument to deny surgical therapy to these patients.

Background The role of telematic surgical approach in gastro-oesophageal reflux disease (GERD) is still unclear.

Background: Surgical cytoreduction and simultaneous hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis is afflicted with a high incidence of postoperative complications. The knowledge of intraoperative volume therapy during surgery and chemotherapy is limited. On the other hand, the choice of a ‘liberal’ or ‘restrictive’ regimen of fluid administration has a deep impact on the postoperative morbidity. The aim of this observational trial was to report detailed data on volume replacement and cardiocircular function during the HIPEC procedure. Methods: Eighteen consecutive patients undergoing cytoreductive surgery and HIPEC for peritoneal carcinomatosis were enrolled. The intraoperative volume administration was observed as well as the postoperative morbidity and mortality. Cardiofunctional data were assessed by the invasive transthoracic thermodilution technique. Results: The study showed that large amounts of volume (1,240 ml h^–1; range: 810–1,570 ml h^–1) are given during the HIPEC procedure to replace fluid loss and maintain a stable circulatory function. Signs of a hyperdynamic status during intraoperative intraperitoneal chemotherapy were not found. Conclusions: During surgical cytoreduction and simultaneous HIPEC, large amounts of volume were administered. HIPEC in itself did not lead to an increased fluid requirement. Further prospective studies with larger populations are needed to investigate whether goal-oriented therapies and a restricted volume regimen can contribute to decrease the postoperative morbidity.