The widespread adoption of Li‐ion batteries is currently limited by their unstable electrochemical performance and high flammability under mechanical deformation conditions and a relatively low energy density. Herein, high‐energy‐density lithium–sulfur (Li–S) batteries are developed for applications in next‐generation flexible electronics and electric vehicles with long cruising distances. Freestanding high‐S‐loading carbon nanotubes cathodes are assembled with a phosphorus (P)‐doped carbon interlayer coated on commercial separators. Strategies for the active materials and structural design of both the electrodes and separators are highly efficient for immobilizing the lithium polysulfides via multimodal capturing effects; they significantly improve the electrochemical performance in terms of the redox kinetics and cycling stability. The foldable Li–S cells show stable specific capacities of 850 mAh g−1 over 100 cycles, achieving high gravimetric and volumetric energy densities of 387 Wh kgcell−1 and 395 Wh Lcell−1, respectively. The Li–S cells show highly durable mechanical flexibilities under severe deformation conditions without short circuit or failure. Finally, the Li–S battery is explored as a light‐weight and flexible energy storage device aboard airplane drones to ensure at least fivefold longer flight times than traditional Li‐ion batteries. Nanocarbon‐based S cathodes and P‐doped carbon interlayers offer a promising solution for commercializing rechargeable Li–S batteries.

Argyrodites, Li6PS5Cl (LPSCl), are considered one of the most promising solid electrolytes (SEs) for all-solid-state batteries (ASSBs). However, the use of petrochemical-based toxic solvents, such as dimethylformamide and tetrahydrofuran (THF),...

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BackgroundTherapeutic approaches using monoclonal antibodies (mAbs) against complement regulatory proteins (CRPs:i.e.,CD46,CD55 and CD59) have been reported for adjuvant cancer therapy. In this study, we generated a recombinant 1E8 single-chain anti-CD59 antibody (scFv-Fc) and tested anti-cancer effect.by using complement dependent cytotoxicity (CDC).MethodsWe isolated mRNA from 1E8 hybridoma cells and amplified the variable regions of the heavy chain (VH) and light chain (VL) genes using reverse-transcriptase polymerase chain reaction (RT-PCR). Using a linker, the amplified sequences for the heavy and light chains were each connected to the sequence for a single polypeptide chain that was designed to be expressed. The VL and VH fragments were cloned into the pOptiVEC-TOPO vector that contained the human CH2-CH3 fragment. Then, 293T cells were transfected with the 1E8 single-chain Fv-Fc (scFv-Fc) constructs. CD59 expression was evaluated in the prostate cancer cell lines using flow cytometry. The enhancement of CDC effect by mouse 1E8 and 1E8 scFv-Fc were evaluated using a cytotoxicity assay.ResultsThe scFv-Fc constructs were expressed by the transfected 293T cells and secreted into the culture medium. The immunoreactivity of the secreted scFv-Fc construct was similar to that of the mouse 1E8 for CCRF-CEM cells. The molecular masses of 1E8 scFv-Fc were about 120 kDa and 55 kDa under reducing and non-reducing conditions, respectively. The DNA sequence of 1E8 scFv-Fc was obtained and presented. CD59 was highly expressed by the prostate cancer cell line. The recombinant 1E8 scFv-Fc mAb revealed significantly enhanced CDC effect similar with mouse 1E8 for prostate cancer cells.ConclusionA 1E8 scFv-Fc construct for adjuvant cancer therapy was developed.

The growth of anodic TiO2 nanotubes with a high layer thickness of greater than 20 μm, “nanograss” structures are typically formed on the outermost surface of TNT walls.