Although nanotopography has been shown to be a potent modulator of cell behavior, it is unclear how the nanotopographical cue, through focal adhesions, affects the nucleus, eventually influencing cell phenotype and function. Thus, current methods to apply nanotopography to regulate cell behavior are basically empirical. We, herein, engineered nanotopographies of various shapes (gratings and pillars) and dimensions (feature size, spacing and height), and thoroughly investigated cell spreading, focal adhesion organization and nuclear deformation of human primary fibroblasts as the model cell grown on the nanotopographies. We examined the correlation between nuclear deformation and cell functions such as cell proliferation, transfection and extracellular matrix protein type I collagen production. It was found that the nanoscale gratings and pillars could facilitate focal adhesion elongation by providing anchoring sites, and the nanogratings could orient focal adhesions and nuclei along the nanograting direction, depending on not only the feature size but also the spacing of the nanogratings. Compared with continuous nanogratings, discrete nanopillars tended to disrupt the formation and growth of focal adhesions and thus had less profound effects on nuclear deformation. Notably, nuclear volume could be effectively modulated by the height of nanotopography. Further, we demonstrated that cell proliferation, transfection, and type I collagen production were strongly associated with the nuclear volume, indicating that the nucleus serves as a critical mechanosensor for cell regulation. Our study delineated the relationships between focal adhesions, nucleus and cell function and highlighted that the nanotopography could regulate cell phenotype and function by modulating nuclear deformation. This study provides insight into the rational design of nanotopography for new biomaterials and the cell–substrate interfaces of implants and medical devices.

Audio-visual recognition (AVR) has been considered as a solution for speech recognition tasks when the audio is corrupted, as well as a visual recognition method used for speaker verification in multi-speaker scenarios. The approach of AVR systems is to leverage the extracted information from one modality to improve the recognition ability of the other modality by complementing the missing information. The essential problem is to find the correspondence between the audio and visual streams, which is the goal of this work. We propose the use of a coupled 3D Convolutional Neural Network (3D-CNN) architecture that can map both modalities into a representation space to evaluate the correspondence of audio-visual streams using the learned multimodal features. The proposed architecture will incorporate both spatial and temporal information jointly to effectively find the correlation between temporal information for different modalities. By using a relatively small network architecture and much smaller dataset for training, our proposed method surpasses the performance of the existing similar methods for audio-visual matching which use 3D CNNs for feature representation. We also demonstrate that an effective pair selection method can significantly increase the performance. The proposed method achieves relative improvements over 20% on the Equal Error Rate (EER) and over 7% on the Average Precision (AP) in comparison to the state-of-the-art method.

In this paper, we propose a deep multimodal fusion network to fuse multiple modalities (face, iris, and fingerprint) for person identification. The proposed deep multimodal fusion algorithm consists of multiple streams of modality-specific Convolutional Neural Networks (CNNs), which are jointly optimized at multiple feature abstraction levels. Multiple features are extracted at several different convolutional layers from each modality-specific CNN for joint feature fusion, optimization, and classification. Features extracted at different convolutional layers of a modality-specific CNN represent the input at several different levels of abstract representations. We demonstrate that an efficient multimodal classification can be accomplished with a significant reduction in the number of network parameters by exploiting these multi-level abstract representations extracted from all the modality-specific CNNs. We demonstrate an increase in multimodal person identification performance by utilizing the proposed multi-level feature abstract representations in our multimodal fusion, rather than using only the features from the last layer of each modality-specific CNNs. We show that our deep multi-modal CNNs with multimodal fusion at several different feature level abstraction can significantly outperform the unimodal representation accuracy. We also demonstrate that the joint optimization of all the modality-specific CNNs excels the score and decision level fusions of independently optimized CNNs.

The state-of-the-art performance of deep learning algorithms has led to a considerable increase in the utilization of machine learning in security-sensitive and critical applications. However, it has recently been shown that a small and carefully crafted perturbation in the input space can completely fool a deep model. In this study, we explore the extent to which face recognition systems are vulnerable to geometrically-perturbed adversarial faces. We propose a fast landmark manipulation method for generating adversarial faces, which is approximately 200 times faster than the previous geometric attacks and obtains 99.86% success rate on the state-of-the-art face recognition models. To further force the generated samples to be natural, we introduce a second attack constrained on the semantic structure of the face which has the half speed of the first attack with the success rate of 99.96%. Both attacks are extremely robust against the state-of-the-art defense methods with the success rate of equal or greater than 53.59%. Code is available at https://github.com/alldbi/FLM.

Elastic distortion of fingerprints has a negative effect on the performance of fingerprint recognition systems. This negative effect brings inconvenience to users in authentication applications. However, in the negative recognition scenario where users may intentionally distort their fingerprints, this can be a serious problem since distortion will prevent recognition system from identifying malicious users. Current methods aimed at addressing this problem still have limitations. They are often not accurate because they estimate distortion parameters based on the ridge frequency map and orientation map of input samples, which are not reliable due to distortion. Secondly, they are not efficient and requiring significant computation time to rectify samples. In this paper, we develop a rectification model based on a Deep Convolutional Neural Network (DCNN) to accurately estimate distortion parameters from the input image. Using a comprehensive database of synthetic distorted samples, the DCNN learns to accurately estimate distortion bases ten times faster than the dictionary search methods used in the previous approaches. Evaluating the proposed method on public databases of distorted samples shows that it can significantly improve the matching performance of distorted samples.