Introduction: With its numerous practical applications, the usage of nanotechnology in the medical profession has been a godsend in our modern technological era. Titanium dioxide (TiO2) is a semiconducting metal oxide with superior inherent qualities which can be utilized in various applications across various fields. Taking into account all of the above information, the current study focused on the mechanism of action of TiO2 nanoparticles mediated by clove and ginger herbal formulations against Lactobacillus species. Materials and Methods: Extract of clove and ginger herbal formulation-mediated TiO2 nanoparticles was obtained with acetone in the ratio of 10:1, yielding 9 mg/mL. After overnight incubation and further serial dilutions, the solution was introduced into microplate wells with cultured Lactobacillus species for 4 hours. A 5% of test solution was added into Kimble tubes containing Muller-Hinton broth along with the plant extract, followed by recording of minimum inhibitory concentrations at certain time intervals. The number of samples used for each concentration was 4 using the convenience method. The grouping sample was 3, i.e. test group, antibiotic and positive control group. The results were statistically analysed following one-way analysis of variances using SPSS software version 22. Result: Optical density determines the degree of scattering of light that is produced by a bacterium within a culture plate. The more the bacteria, the more the light is scattered. The results ( P < .005) show that as the concentration increases, the value of optical density decreases which proves that there occurs a bactericidal process that results in the reduced bacterial count. Conclusion: The results of this study suggest that TiO2 nanoparticles enhanced with clove and ginger might be used as an antibacterial agent against Lactobacillus species.

Introduction: The unnamed openings present in mandible are called accessory foramina. The distribution and importance of these foramina are variable, as they may serve as a conduct for nerve fibres or blood vessels. They may be important for dental surgeon and anaesthetists in performing complete nerve block and avoiding injury to the transverse get neurovascular structures. Materials & Methods: In the present study a total of 50 dry human mandibles of unknown sex and without any gross abnormality were collected from the Department of Anatomy, Saveetha Dental College, Chennai for evaluation. With the help of Vernier Calliper and Ruler, the measurements like the length, breadth and diameter of sacral hiatus will be measured. The results obtained were analysed, tabulated and represented graphically. Results: The Accessory foramina on the  internal surface of the mandible was examined.Frequency of accessory mandibular foramen in 0.5mm is 40% ,in 1.0mm is 18%, in 1.5mm is 9%. Frequency of accessory mental foramen and frequency of accessory  retromolar foramen in  0.25mm is 20% and 9% respectively.Conclusion: The accessory foramina transmitting during nerve block.

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First identified by the Egyptians in 2640 BC, podagra (acute gout occurring in the first metatarsophalangeal joint) was later recognized by Hippocrates in the fifth century BC, who referred to it as 'the unwalkable disease'. The term is derived from the Latin word gutta (or 'drop'), and referred to the prevailing medieval belief that an excess of one of the four 'humors' - which in equilibrium were thought to maintain health - would, under certain circumstances, 'drop' or flow into a joint, causing pain and inflammation. Throughout history, gout has been associated with rich foods and excessive alcohol consumption. Because it is clearly associated with a lifestyle that,atleast in the past, could only be afforded by the affluent, gout has been referred to as the 'disease of kings'. Although there is evidence that colchicine, an alkaloid derived from the autumn crocus (Colchicum autumnale), was used as a powerful purgative in ancient Greece more than 2000 years ago, its first use as a selective and specific treatment for gout is attributed to the Byzantine Christian physician Alexander of Tralles in the sixth century AD.