Background Epidemiologic studies on Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) currently estimate the risk between 1:300 and 1:30,000, assessed mainly in large breast reconstruction populations. Objectives Aims of the study was to assess BIA-ALCL epidemiology in a cohort of patients who have received textured implants for cosmetic indications. Methods In a prospective cohort observational study, 1,501 patients who received a cosmetic breast augmentation, between 2006 and 2016, were monitored recording any implant-related complication, including BIA-ALCL. Cross-checking clinical, pathology and external records data was used to identify cases. Prevalence, Implant-Specific Prevalence (I-SP), Incidence Rate (IR), Event Free Time (EFT) and Kaplan Meier survival estimate were calculated. Results All but 2 patients received macrotextured or microtextured devices bilaterally. Mean follow-up was 3.2 years (1 months to 16.4 years). Five BIA-ALCL cases were investigated, prevalence was 1:300 patients, I-SP was 6.9 cases/1000 individuals/BIOCELL and 1.3 cases/1000 individuals/Siltex devices, IR was 1.07 cases/1,000 women/year. Mean (SD) EFT was of 9.2 years. Conclusions When using a denominator based on a cohort of cosmetic patients, BIA-ALCL occurrence is higher than previously reported, particularly with macrotextured devices. Given the similar IR between reconstructive and cosmetic cohorts, their even distribution can be consequent to underreporting due to poorer follow up and lower awareness in the latter group. The genetic predisposition in oncologic cohort reasonably affects the early onset more than the IR. Importance of accurate follow-up is confirmed. Stratification risks analysis can guide surgeons during patient’s counseling in the decision for prophylactic explantation.

Current treatment protocols for myocardial infarction improve the outcome of disease to some extent but do not provide the clue for full regeneration of the heart tissues. An increasing body of evidence has shown that transplantation of cells may lead to some organ recovery. However, the optimal stem cell population has not been yet identified. We would like to propose a novel pro-regenerative treatment for post-infarction heart based on the combination of human skeletal myoblasts (huSkM) and mesenchymal stem cells (MSCs). huSkM native or overexpressing gene coding for Cx43 (huSKMCx43) alone or combined with MSCs were delivered in four cellular therapeutic variants into the healthy and post-infarction heart of mice while using molecular reporter probes. Single-Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) performed right after cell delivery and 24 h later revealed a trend towards an increase in the isotopic uptake in the post-infarction group of animals treated by a combination of huSkMCx43 with MSC. Bioluminescent imaging (BLI) showed the highest increase in firefly luciferase (fluc) signal intensity in post-infarction heart treated with combination of huSkM and MSCs vs. huSkM alone (p < 0.0001). In healthy myocardium, however, nanoluciferase signal (nanoluc) intensity varied markedly between animals treated with stem cell populations either alone or in combinations with the tendency to be simply decreased. Therefore, our observations seem to show that MSCs supported viability, engraftment, and even proliferation of huSkM in the post-infarction heart.

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ongenital amniotic band syndrome (ABS) is an anomaly with no proven etiology occurring in 0.7 per 10,000 live births. 1 This defect mostly concerns the extremities and is often accompanied by other developmental anomalies. 2 There are many methods of treatment for this type of defect. [3][4][5] The literature most often describes cases of treated children. There are no case reports of ABS treatment in adults. However, failure to undertake such treatments in childhood may result in serious mental dysfunction. [6][7][8][9] Here, we present a rare case of ABS in an adult patient and describe our management approach.

Hair is an inseparable element of external appearance of every human being. Although various fashion trends come and go, the lack of hair is for many a major aesthetic and psychological problem. Even if men's balding can be accepted as a natural phenomenon, hair loss in children is considered to be a condition demanding correction. During an 18-year period, 8440 hair restoration operations were performed at the Hair Clinic Poznan, in Poznan, Poland. Most patients were men treated for androgenic alopecia. Among the patients were 57 children in whom hair loss resulted from hereditary factors, perinatal traumas, radiotherapy, and mechanical, thermal, and chemical damage. Methods of restoration were adjusted to type of hair loss, patient age, and ability to cooperate with the surgeon. In cases of single massive scars, skin flap correction was usually used. The flaps were prepared with the use of expanders. In cases of numerous scattered defects or considerable thinning of the scalp, the method of choice was hair transplantation. The "four-hand stick-and-place" technique developed by the authors enabled the surgeon to quickly and precisely carry out the procedure. Application of varied surgery techniques in scalp reconstruction procedures in children gave very good aesthetic results with a minimal complication rate.