One in eight children in the United States grows up in a household with parental substance use disorder (SUD). The purpose of this study was to explore the needs of children and kinship caregivers affected by SUD, as perceived by 23 professionals who interact with these families. A community-based participatory research approach with exploratory and descriptive qualitative methods was utilized. Results indicated that (a) children need relationships and connections, stability, emotional and health care support, and protection from risks associated with SUD; (b) caregivers need community resource and navigation supports, skills development, and understanding of the caregiver’s role; and (c) there is a lack of existing comprehensive resources and services to support families affected by SUD. This study adds to existing literature by identifying key professionals’ perceptions and examining various types of kin relationships. Future research and practice implications are discussed.