A common measure of memory monitoring--judgments of learning (JOLs)--has recently been shown to have reactive effects on learning. When participants study a list of related and unrelated word pairs, they recall more related than unrelated pairs. This relatedness effect is larger when people make JOLs than when they do not make them. Evidence is mixed concerning whether this increased relatedness effect arises because JOLs help memory for related pairs, hurt it for unrelated pairs, or do both. In three experiments, we investigated (1) the nature of the increased relatedness effect (i.e., does it arise from positive reactivity for related pairs, negative reactivity for unrelated pairs, or both?) and (2) the mechanisms underlying the effect. Participants studied cue-target word pairs and either did (or did not) make immediate JOLs and then completed a cued-recall test. When participants studied a mixed list consisting of related and unrelated pairs, the increased relatedness effect was largely driven by positive reactivity. When participants studied pure lists consisting solely of related or unrelated word pairs (Experiment 2 only), the increased relatedness effect was minimized. These and other findings suggest that making JOLs helps learning more than hurts it, and that this reactive effect partly occurs because making JOLs changes people's learning goals.

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Summary Successive relearning combines two effective learning techniques (retrieval practice and spaced practice) and involves practicing retrieval until some level of mastery has been reached (i.e., at least one correct retrieval attempt) in each of multiple sessions. Several laboratory studies have demonstrated the promise of successive relearning for enhancing student learning, but attempts to evaluate its effectiveness in authentic educational contexts are limited. In the current research, we implemented successive relearning in a difficult biopsychology course to examine its effectiveness at enhancing student learning on a high‐stakes exam. Students successively relearned some course content via a virtual flashcard program, whereas other course content was learned with business‐as‐usual activities. In two experiments, successive relearning boosted students' learning of course content by at least 10% (with ds ranging from 0.54 to 1.10). These findings suggest that implementing successive relearning in courses can be an effective method of promoting student achievement.

Rationale & Objective Low serum magnesium level has been shown to be associated with increased mortality, but its role as a predictor of cardiovascular disease is unclear. This study evaluates the association between serum magnesium level and cardiovascular events and all-cause mortality in a large cohort of individuals with chronic kidney disease (CKD). Study Design Prospective cohort study. Setting & Participants 3,867 participants with CKD, enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study. Exposures Serum magnesium measured at study baseline. Outcomes Composite cardiovascular events (myocardial infarction, cerebrovascular accident, heart failure, and peripheral arterial disease) and all-cause mortality. Analytical Approach Cox proportional hazards models adjusted for demographic, clinical, and laboratory characteristics. Results During the 14.6 (4.4) years (standard deviation) of follow-up, 1,384 participants died (36/1,000 person-years), and 1,227 (40/1,000 person-years) had a composite cardiovascular event. There was a nonlinear association between serum magnesium level and all-cause mortality. Low and high magnesium levels were associated with greater rates of all-cause mortality after adjusting for demographics, comorbid conditions, medications including diuretics, estimated glomerular filtration rate, and proteinuria ( P < 0.001). No significant associations were observed between serum magnesium levels and the composite cardiovascular events. Low serum magnesium level was associated with incident atrial fibrillation (HR, 1.36; 95% CI, 1.01-1.82; P = 0.04). Limitations Single measurement of serum magnesium. Conclusions In this large CKD cohort, serum magnesium level < 1.9 mg/dL and >2.1 mg/dL was associated with increased risk for all-cause mortality. Low magnesium level was associated with incident atrial fibrillation but not with composite cardiovascular disease events. Further studies are needed to determine the optimal range of serum magnesium in CKD to prevent adverse clinical outcomes.

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