In utero experience, such as maternal speech in humans, can shape later perception, although the underlying cortical substrate is unknown. In adult mammals, ascending thalamocortical projections target layer 4, and the onset of sensory responses in the cortex is thought to be dependent on the onset of thalamocortical transmission to layer 4 as well as the ear and eye opening. In developing animals, thalamic fibers do not target layer 4 but instead target subplate neurons deep in the developing white matter. We investigated if subplate neurons respond to sensory stimuli. Using electrophysiological recordings in young ferrets, we show that auditory cortex neurons respond to sound at very young ages, even before the opening of the ears. Single unit recordings showed that auditory responses emerged first in cortical subplate neurons. Subsequently, responses appeared in the future thalamocortical input layer 4, and sound-evoked spike latencies were longer in layer 4 than in subplate, consistent with the known relay of thalamic information to layer 4 by subplate neurons. Electrode array recordings show that early auditory responses demonstrate a nascent topographic organization, suggesting that topographic maps emerge before the onset of spiking responses in layer 4. Together our results show that sound-evoked activity and topographic organization of the cortex emerge earlier and in a different layer than previously thought. Thus, early sound experience can activate and potentially sculpt subplate circuits before permanent thalamocortical circuits to layer 4 are present, and disruption of this early sensory activity could be utilized for early diagnosis of developmental disorders.

These results emphasize the need for interaural alignment-in timing and especially in frequency-to maximize contralateral unmasking for NH listeners presented with vocoder simulations of SSD-CI listening. Improved processing strategies that reduce mismatch between the electric and acoustic ears of SSD-CI listeners might improve their ability to obtain binaural benefits in multitalker environments.

Purpose For listeners with single-sided deafness, a cochlear implant (CI) can improve speech understanding by giving the listener access to the ear with the better target-to-masker ratio (TMR; head shadow) or by providing interaural difference cues to facilitate the perceptual separation of concurrent talkers (squelch). CI simulations presented to listeners with normal hearing examined how these benefits could be affected by interaural differences in loudness growth in a speech-on-speech masking task. Method Experiment 1 examined a target–masker spatial configuration where the vocoded ear had a poorer TMR than the nonvocoded ear. Experiment 2 examined the reverse configuration. Generic head-related transfer functions simulated free-field listening. Compression or expansion was applied independently to each vocoder channel (power-law exponents: 0.25, 0.5, 1, 1.5, or 2). Results Compression reduced the benefit provided by the vocoder ear in both experiments. There was some evidence that expansion increased squelch in Experiment 1 but reduced the benefit in Experiment 2 where the vocoder ear provided a combination of head-shadow and squelch benefits. Conclusions The effects of compression and expansion are interpreted in terms of envelope distortion and changes in the vocoded-ear TMR (for head shadow) or changes in perceived target–masker spatial separation (for squelch). The compression parameter is a candidate for clinical optimization to improve single-sided deafness CI outcomes.

For single-sided deafness cochlear-implant (SSD-CI) listeners, different peripheral representations for electric versus acoustic stimulation, combined with interaural frequency mismatch, might limit the ability to perceive bilaterally presented speech as a single voice. The assessment of binaural fusion often relies on subjective report, which requires listeners to have some understanding of the perceptual phenomenon of object formation. Two experiments explored whether binaural fusion could instead be assessed using judgments of the number of voices in a mixture. In an SSD-CI simulation, normal-hearing listeners were presented with one or two "diotic" voices (i.e., unprocessed in one ear and noise-vocoded in the other) in a mixture with additional monaural voices. In experiment 1, listeners reported how many voices they heard. Listeners generally counted the diotic speech as two separate voices, regardless of interaural frequency mismatch. In experiment 2, listeners identified which of two mixtures contained diotic speech. Listeners performed significantly better with interaurally frequency-matched than with frequencymismatched stimuli. These contrasting results suggest that listeners experienced partial fusion: not enough to count the diotic speech as one voice, but enough to detect its presence. The diotic-speech detection task (experiment 2) might provide a tool to evaluate fusion and optimize frequency mapping for SSD-CI patients.