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AimsA growing body of evidence suggests that ethnicity and race influence vitamin B12 metabolism and status yet clinical awareness of this is poor, causing doubts regarding diagnosis and treatment. Moreover, deficiency and insufficiency cut-offs are universally applied for this test in most diagnostic settings. The objective of this study was to assess serum vitamin B12 concentrations in Black, Asian and White primary care patients in London, UK, particularly in patients of Black or Black British ethnic origin and establish if there is a need for specific reference ranges.MethodsSerum B12 results from 49 414 patients were processed between January 2018 and November 2019 using the Architect assay (Abbott Diagnostics) at St. Thomas’ Hospital, London, UK. Age, sex and ethnicity data were collected from the laboratory Health Informatics Team.ResultsBlack patients (n=13 806) were found to have significantly higher serum vitamin B12 concentration across all age groups and both sexes, especially Nigerian patients (median B12 505 pmol/L,IQR: 362–727, n=891), compared with Asian and White ethnic groups (p<0.001). Binary logistic regression analysis revealed that the Black or Black British ethnic group had the strongest association with elevated serum B12 (>652 pmol/L) (adjusted OR 3.38, 95% CI 3.17 to 3.61, p<0.0001).ConclusionsIt is likely that a combination of genetic and acquired/environmental factors are responsible for the ethnic differences in serum B12. This suggests that there is a need for ethnic-specific reference ranges with indications for the incorporation of age and sex too.

High-performance disciplines have always been concerned with safety and exceptional performance. They have established a culture of vigilance and accepted that human error is both inevitable and ubiquitous. These disciplines, therefore, have all implemented a 'systems approach' to error by focusing on predicting, preventing, rescuing and reporting errors that occur so that they can constantly adapt and improve. Given the complexity of surgery, and the error-prone environment within which it takes place, extracting positive behaviours from other high-performance disciplines will serve to improve performance and enhance patient safety. Surgery is being practiced in an ever-changing environment. Currently, there is less available operative experience for surgical trainees; multi-morbidity in patients is growing and rapidly evolving technology means that more high-tech equipment is being used in procedures. This article evaluates the effectiveness of current surgical protocol in reducing errors and possible modifications that can be made to fit the new environment that surgery is now being practiced in. It will then describe how three different high-performance disciplines: aviation, professional sport and Formula 1, have developed in their approaches to safety and excellence, which will serve as the basis for a discussion about what more can be learnt from these disciplines so that the surgical profession can continue to excel in the face of change.