While sleep deficits in adulthood are common and worsening, college females experience significantly more sleep problems and depression than their male counterparts. In recent years, sleep has been investigated as one of the primary contributors to college functioning and GPA. No known study, however, has investigated the connection between self-esteem, depression and sleep. Questionnaire assessments were given to 42 female college juniors and seniors, including: demographic information, Rosenberg Self-esteem Scale, Beck Depression Inventory, and Pittsburg Quality Sleep Index. The current study investigates the relation between college selfesteem and sleep quality, as mediated by depression. The results of the study indicate that selfesteem predicts both depression and sleep quality, such that decreased levels of self-esteem are associated with higher levels of depression and decreased sleep quality. Moreover, depression also predicts sleep quality. Further, depression serves to mediate the relation between self-esteem and sleep quality. The results suggest that students' self-esteem plays a significant role in the experience of depression and that depression is the primary mechanism through which selfesteem influences sleep. College administrators should consider integrating self-esteem promotion strategies into their campus wide intervention efforts to promote mental health and academic success.