tea-containing mouthwash compared with chlorhexidine and placebo saline mouthwash 1 . Patients were 9 to 60 years old (mean age not provided) from India, Thailand, and Iran without a diagnosis diabetes. Patients were instructed to rinse twice a day with 10 to 15 mL of test solution for at least 60 seconds (4 RCTs) or provided hygiene instructions without a specific rinse protocol (1 RCT). A specific brushing technique was taught in one RCT with routine oral home care with their usual toothbrush routine and paste in the other four RCTs. Green tea mouth wash concentrations ranged from 0.5% to 5%. Chlorhexidine mouth wash concentrations ranged from 0.12% to 0.2%. Patients received saline for placebo. Length of studies was from 14 to 28 days. Outcomes were based on the change of plaque index (which assesses the thickness of plaque at the cervical margin of the tooth on a scale of 0-3 for increasing thickness) and gingival index (assesses the severity of gingivitis based on color, consistency, and bleeding because of probing, scored on an increasing 0-3 scale based on severity). The change in the plaque index was no different between green tea and chlorhexidine (3 RCTs, N5110; mean difference [MD] 0.04; 95% CI, -0.06 to 0.15, I 2 50%) or green tea and placebo (2 RCTs, N5170; MD 0.9; 95% CI, -0.8 to 2.5, I 2 50%) at the endpoint of the study. The change in gingival index was no different between green tea and chlorhexidine (3 RCTs, N5110; MD -0.01; 95% CI, -0.07 to 0.05) or green tea and placebo (2 RCTs, N5170; MD 0.29; 95% CI, -0.33 to 0.90) at the endpoint of the study. This analysis was limited by a short follow-up period (max of 28 days) compared with the American Dental Association's recommended six months of treatment to assess effectiveness.In 2018, a double-blind RCT (n552) compared green tea, chlorhexidine, probiotics, and fluoride-containing toothpaste on oral microbial flora. 2 Patients were 18 to 25 years old with mild-to-moderate gingivitis who had not used antibiotics within three months, had no allergies to the products used, and were not undergoing orthodontic treatment. They were followed for a total of 30 days. On days 15 and 30, researchers took samples from plaque and saliva and measured for Streptococcus mutans and Lactobacillus. Chlorhexidine reduced the bacterial colony count for S mutans (MD 120,000; P,.05) and Lactobacillus (MD 8,000; P,.05), whereas green tea did not show a difference for S mutans (MD 67,000; P..05) or Lactobacillus (MD 4,000; P,.05).