Abstract. Recent evidences of the impact of persistent modes of regional climate variability, coupled with the intensification of human activities, have led hydrologists to study flood regime without applying the hypothesis of stationarity. In this study, a framework for flood frequency analysis is developed on the basis of a tool that enables us to address the modelling of non-stationary time series, namely, the "generalized additive models for location, scale and shape" (GAMLSS). Two approaches to non-stationary modelling in GAMLSS were applied to the annual maximum flood records of 20 continental Spanish rivers. The results of the first approach, in which the parameters of the selected distributions were modelled as a function of time only, show the presence of clear non-stationarities in the flood regime. In a second approach, the parameters of the flood distributions are modelled as functions of climate indices (Arctic Oscillation, North Atlantic Oscillation, Mediterranean Oscillation and the Western Mediterranean Oscillation) and a reservoir index that is proposed in this paper. The results when incorporating external covariates in the study highlight the important role of interannual variability in low-frequency climate forcings when modelling the flood regime in continental Spanish rivers. Also, with this approach it is possible to properly introduce the impact on the flood regime of intensified reservoir regulation strategies. The inclusion of external covariates permits the use of these models as predictive tools. Finally, the application of non-stationary analysis shows that the differences between the non-stationary quantiles and their stationary equivalents may be important over long periods of time.

Recent evidences of the impact of persistent modes of regional climate variability, coupled with the intensification of human activities, have led hydrologists to study flood regime without applying the hypothesis of stationarity. In this study, a framework for flood frequency analysis is developed on the basis of a tool that enables us to address the modelling of non-stationary time series, namely, the "generalized additive models for location, scale and shape" (GAMLSS). Two approaches to non-stationary modelling in GAMLSS were applied to the annual maximum flood records of 20 continental Spanish rivers. The results of the first approach, in which the parameters of the selected distributions were modeled as a function of time only, show the presence of clear non-stationarities in the flood regime. In a second approach, the parameters of the distributions are modeled as functions of climate indices (Arctic Oscillation, North Atlantic Oscillation, Mediterranean Oscillation and the Western Mediterranean Oscillation) and a reservoir index that is proposed in this paper. The results when incorporating external covariates in the study highlight the important role of interannual variability in low-frequency climate forcings when modelling the flood regime in continental Spanish rivers. Also, with this approach is possible to properly introduce the impact on the flood regime of intensified reservoir regulation strategies and to be used as predictive tools. Application of non-stationary analysis shows that the differences between the quantiles obtained and their stationary equivalents may be important over long periods of time

Abstract. Historical records are an important source of information on extreme and rare floods and fundamental to establish a reliable flood return frequency. The use of long historical records for flood frequency analysis brings in the question of flood stationarity, since climatic and land-use conditions can affect the relevance of past flooding as a predictor of future flooding. In this paper, a detailed 400 yr flood record from the Tagus River in Aranjuez (central Spain) was analysed under stationary and non-stationary flood frequency approaches, to assess their contribution within hazard studies. Historical flood records in Aranjuez were obtained from documents (Proceedings of the City Council, diaries, chronicles, memoirs, etc.), epigraphic marks, and indirect historical sources and reports. The water levels associated with different floods (derived from descriptions or epigraphic marks) were computed into discharge values using a one-dimensional hydraulic model. Secular variations in flood magnitude and frequency, found to respond to climate and environmental drivers, showed a good correlation between high values of historical flood discharges and a negative mode of the North Atlantic Oscillation (NAO) index. Over the systematic gauge record , an abrupt change on flood magnitude was produced in 1957 due to constructions of three major reservoirs in the Tagus headwaters (Bolarque, Entrepeñas and Buendia) controlling 80 % of the watershed surface draining to Aranjuez. Two different models were used for the flood frequency analysis: (a) a stationary model estimating statistical distributions incorporating imprecise and categorical data based on maximum likelihood estimators, and (b) a time-varying model based on "generalized additive models for location, scale and shape" (GAMLSS) modelling, which incorporates external covariates related to climate variability (NAO index) and catchment hydrology factors (in this paper a reservoir index; RI). Flood frequency analysis using documentary data (plus gauged records) improved the estimates of the probabilities of rare floods (return intervals of 100 yr and higher). Under nonstationary modelling flood occurrence associated with an exceedance probability of 0.01 (i.e. return period of 100 yr) has changed over the last 500 yr due to decadal and multidecadal variability of the NAO. Yet, frequency analysis under stationary models was successful in providing an average discharge around which value flood quantiles estimated by non-stationary models fluctuate through time.

The degree of effectiveness of mosquito nets against malaria in the Americas has remained uncertain. We carried out a case-control study of net use and mild malaria in the Amazonas state of Colombia. Two hundred ninety cases were enrolled via the Health Department services, and 977 community-based controls matched for age, sex, and place of residence. We found that a large proportion of the population (96% of controls) slept under nets. Nevertheless, we found a benefit of impregnated nets compared with no net use: adjusted odds ratio (OR) for mild malaria 0.44, 95% confidence interval (CI) 0.20-0.98. Nonimpregnated nets had a benefit that was only slightly smaller but not statistically significant (OR for mild malaria 0.54, 95% CI 0.25-1.18). Travel in the previous month had an odds ratio of 6.2 (95% CI 3.1-8.8) and a population attributable fraction of 13% compared with 11% for failure to use an impregnated net. We conclude that, in the Amazon region, promotion of mosquito net use and impregnation is justified, and that there is a need for measures to protect travelers from malaria.

Abstract. Historical records are an important source of information about extreme and rare floods with a great value to establish a reliable flood return frequency. The use of long historic records for flood frequency analysis brings in the question of flood stationarity, since climatic and land-use conditions can affect the relevance of past flooding as a predictor of future flooding. In this paper, a detailed 400 year flood record from the Tagus River in Aranjuez (Central Spain) was analysed under stationary and non-stationary flood frequency approaches, to assess their implications on hazard studies. Historical flood records in Aranjuez were obtained from documents (Proceedings of the City Council, diaries, chronicles, memoirs, etc.), epigraphic marks, and indirect historical sources and reports. The water levels associated with different floods (derived from descriptions or epigraphic marks) were computed into discharge values using a one-dimensional hydraulic model. Secular variations on flood magnitude and frequency, found to respond to climate and environmental drivers, showed a good correlation between high values of historical flood discharges and a negative mode of the North Atlantic Oscillation index (NAO index). Over the systematic gauge record (1913–2008), an abrupt change on flood magnitude was produced in 1957 due to constructions of three major reservoirs in the Tagus headwaters (Bolarque, Entrepeñas and Buendia) controlling 80% of the watershed surface draining to Aranjuez. Two different models were used for the flood frequency analysis: (a) a stationary model estimating statistical distributions incorporating imprecise and categorical data based on maximum likelihood estimators; (b) a time–varying model based on "generalized additive models for location, scale and shape" (GAMLSS) modelling, that incorporates external covariates related to climate variability (NAO index) and catchment hydrology factors (in this paper a reservoir index; RI). Flood frequency analysis using documentary data (plus gauged record) improved the estimates of the probabilities of rare floods (return intervals of 100 year and higher). Under non-stationary modelling flood occurrence associated with an exceedance probability of 0.01 (i.e. return period of 100 year) has changed over the last 500 year due to decadal and multi-decadal variability of the NAO. Yet, frequency analysis under stationary models was successful on providing an average discharge around which value flood quantiles estimated by non-stationary models fluctuate through time.