The incidence of OGT in the southeast of Spain is very high, being in most cases produced by accidents while using wire in greenhouses. This provokes severe monocular visual loss among the young population.

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ObjectiveTo describe the prevalence of congenital anophthalmia and microphthalmia in Hospital Universitario La Paz, and to identify associated risk factors and evaluate cosmetic results in treated and nontreated patients.MethodsA retrospective, descriptive, cross-sectional study of patients treated with orbital expanding techniques (cases) and nontreated patients (controls) was carried out as a comparative case series study. A total of 36 patients with unilateral or bilateral anophthalmia or microphthalmia as main diagnosis were included; 52 epidemiological and management variables for each patient were analyzed. The study evaluated orbital growth and facial symmetry.ResultsThe overall cosmetic result in the study’s group of patients was satisfactory: 66.7% showed good or very good orbital growth, and 75% showed good or very good facial symmetry. Controls had better cosmetic outcome but showed more cataracts (P = 0.05), inferior colobomas (P = 0.026), and family history (P = 0.056) than the cases. Controls also showed significantly better orbital growth (P = 0.042) and facial symmetry (P = 0.014) than the cases.ConclusionThis study suggests that the mere presence of a globe (controls) still provides better orbitofacial development than the artificial stimulation (cases) currently available for patients with congenital anophthalmia and microphthalmia, who receive internal and external orbital rehabilitation.

Results. As shown in the Table, by comparison with the GG genotype, the TT genotype was associated with very high risk for all types of ARM, with increasing odds ratios according to the severity of ARM (from 4.60 for early ARM1 to 23.63 and 16.15 for late atrophic and neovascular ARM, respectively). By contrast, associations of the different types of ARM with the GT genotype were modest (OR, 1.45-2.47) and reached statistical significance only for early ARM1. Smoking and CFH Y402H remained independently associated with ARM, after controlling for ARMS A69S genotypes (data not shown). Comment. This population-based study confirms the major contribution of the TT genotype of the ARMS2 A69S polymorphism in early and late ARM, independently from the other 2 major risk factors (smoking and CFH Y402H polymorphism). Associations with the GT genotypes were much weaker, suggesting a moderate codominant genetic mode of action. Strengths of this study include the population-based setting and the photographic assessment and detailed grading of ARM status.

Total serous retinal detachment is a rare but severe visual complication in retinopathy of prematurity. The described technique may restore the retinae immediately in a visually critical period.