Background: the emergence of new drugs for cancer treatment has reflected on increasing patient survival. However, these drugs bring side effects, such as dry mouth sensation and hyposalivation. This study aimed to evaluating the relationship between patients with cancer and xerostomia and hyposalivation. Method : cross-sectional study with 114 patients diagnosed with cancer treated with anastrozole and / or bicalutamide. Age, type of neoplasia, gender, xerostomia, and type of medicine were obtained through questionnaire. Resting and stimulated salivary flow were collected by the researcher. After collection, using a 10 mL disposable syringe, salivary flow was quantified in millimeters and divided into 6 (collection period). A Descriptive statistical analysis, Chi-square test and T-test were carried out through Statistical Package for Social Science® (SSPS) version 21, considering p<0.05. Results : results showed that 67 (55.8%) patients who use hormone therapy presented hyposalivation and 73 (64. 0%) patients presented xerostomia. Conclusion : According to the results from this study, there is statistically significant association between stimulated hyposalivation and hormone therapy usage (p = 0.015). Statistically significant association was also observed among hyposalivation and xerostomia and hormone therapy usage (p=0.049 and p = 0.001).

Background: The appearance of new drugs for cancer treatment has increased patient survival but it has also brought adverse effects, such as the sensation of dry mouth and hyposalivation. Objective: To assess the relationship of using hormone therapy in breast and prostate cancer patients and the occurrence of xerostomia and hyposalivation. Method: Cross-sectional study with 114 patients diagnosed with cancer and treated with hormone therapy (anastrozole or bicalutamide). Age, type of neoplasia, sex, presence of xerostomia (yes or no), and type of medication were obtained with a questionnaire. The researcher collected resting and stimulated salivary flows in the morning. The descriptive statistic analysis, chi-square test (p<0.005), and t-test (<0.005) were performed using the Statistical Package for Social Science™ (SSPS), version 21, for different variables of hyposalivation and hormone therapy. Results: The results showed that 67 (55.8%) patients using hormone therapy drugs presented hyposalivation and 73 (64%) patients presented xerostomia. Conclusion: According to the results of this study, there is a positive association between stimulated hyposalivation and the use of hormone therapy drugs (p = 0.015). There was also a positive association between hyposalivation and xerostomia and the use of hormone therapy drugs (p = 0.049 and p = 0.001).