The expression “There is nothing more political than the tits of a transgender” shows a politicization of the body; an act of rebellion and resistance that oversteps the traditionally established social order. This exercise is guided by the life story of a transfeminist, Ana Lu Laferal, and an indigenous trans woman, Geraldín, who based on their personal experience will help us understand the following: What happens when individuals distance themselves from the heterosexual hegemonic ideal of the body that has been defined by certain biological characteristics? Is the body a tool of political agency for transgender people? All this seeks to understand how trans people configure subjectivity and the capacity of political agency —from the empowerment of their body and the use of this tool— as a first scenario of resistance. One of the strategies deployed to show the trans experience is the use of a comprehensive language, which becomes a tool to acknowledge other ways of being and defend the right to self-recognition. In short, this work studies other political forms that are constituted from otherness, subjectivity, and individuality, in which the body is used as a means and an end.