The aim of this study was to describe the clinical, gross and microscopic lesions as diagnostic methods pemphigus foliaceus (PF) in an imported horse Silla Argentino, castrated male, 9 years old from the municipality of Montería (Córdoba, Colombia). In describing the clinical case, the presence of scabs generalized mainly at the level of the chest and abdomen, initially presented ventral edema and some areas had pustules and vesicles, as well as fever and marked pruritus was observed. The lesions were located bilaterally at the level of face, thoracic region, abdominal, gluteal and limbs. Histopathological in the HE stain, was observed the presence of acantholytic keratinocytes and areas acantholytic sloughing in the granular layer, hyperplasia and epidermal desquamation; areas subepidermal spongiosis and various subcorneal pustules characterized by the presence of intact neutrophils and degenerate and dermal edema hyalinization moderate collagen, likewise in TG staining, poor dermal collagen proliferation disorganized with little presence of diffuse connective tissue was observed, while in the PR/P staining, areas of red birefringence was observed, indicating moderate presence of mature type I collagen (red bright polarization). The diagnosis was based on clinical signs, histopathological findings, differential diagnosis and response to medical treatment. In the literature there are no reports of PF in the Department, so it is the first report of this disease in horses of Córdoba.