This study aims to determine the effect of competence, work ethic, work discipline, and work motivation on the performance of the government employee. This research is motivated by the ability or competence of the government employee is still low, not all government employee comply with regulations provided by the agency, agency performance targets have not been achieved, the work ethic is still low, the motivation that supports the performance of the government employee is not optimal, awareness responsibility and work discipline are still low. the performance of the government employee is still unstable at the Mentawai Islands District Health Office. This type of research uses a quantitative approach with multiple linear regression methods. Data collection techniques with questionnaires, observation and interviews. The respondents of this study were 60 government employees in the Mentawai Islands District Health Office. The sampling method uses the total sampling method in which the entire population in this study is the research sample. Hypothesis testing was calculated with the IBM Statistical Package for Social Science (SPSS) program version 24.0. From the results of this study it was found that competency partially has a significant effect on the performance of the government employee, work ethic partially has a significant effect on the performance of the government employee, work discipline partially has a significant effect on the performance of the government employee, work motivation partially has a significant effect on the performance of the government employee and competence (X1), work ethic (X2), work discipline (X3), and work motivation (X4) together have a significant effect on the performance of the government employee in the Mentawai Islands District Health Office.