No abstract

Background An antimicrobial stewardship program (ASP), aiming to optimize antimicrobial usage, was implemented at a Veterans Affairs Health Care System (VA HCS). Objective The main objective of this study was to compare antimicrobial usage before and after implementation of an ASP and to assess ASP interventions. Method This retrospective study was conducted at the Fargo VA HCS. A total of 1,017 inpatient charts were reviewed for 2 distinct time periods, February through September 2008 (pre ASP) and February through September 2010 (post ASP). The data that were collected and analyzed included the number of hospitalized patients prescribed antimicrobials, antimicrobial therapy duration, duration of hospital stay, and inpatient antimicrobial costs. Subgroup analyses were performed on the top 5 antimicrobials and the top 6 indications. The number, types of, and overall acceptance rate of ASP interventions were also assessed. Results When the pre- to post-ASP periods were compared, the percentage of patients on antimicrobial therapy decreased from 36.8% to 25% (P < .001), the median duration of antimicrobial therapy significantly decreased (P = .02), and the defined daily dose (DDD) per 1,000 patient bed days was reduced for piperacillin/tazobactam, vancomycin, and ciprofloxacin. In addition, the total inpatient antimicrobial costs decreased by $48,044 (25%). The overall ASP intervention acceptance rate was 81.6% (315 out of 386 total interventions). Conclusion The results of this study show that ASP implementation has been highly accepted by providers and has been associated with a reduction in the number of patients prescribed antimicrobials, median duration of antimicrobial therapy, and antimicrobial inpatient costs.

Purpose: To determine the Clostridium difficile infection (CDI) recurrence rate at the Veterans Affairs Medical Center (VAMC) in Fargo, North Dakota, and to determine whether certain variables (eg, type of antibiotic, medication, chronic disease state, CDI symptom control) were predictive of CDI recurrence. Methods: Demographic information and laboratory data from 174 adult outpatients and inpatients were collected from electronic medical records between January 1997 and September 2009. In addition, information about the duration of non-CDI antibiotic therapy and the use of proton pump inhibitors, histamine H2 blockers, corticosteroids, and immunosuppressive medications within 60 days of CDI was collected. Information regarding comorbid conditions (eg, cancer, liver or renal disease, diabetes, chronic heart failure) in patients at the time of CDI was also collected. Results: Patients below the median age of 69.5 years were more likely to continue to have diarrhea after CDI treatment than patients who were older than the median age (relative risk 1.86; 95% CI, 1.06-3.26). No association was observed between previous non-CDI treatment antibiotic use, other medication use, or comorbid conditions and the recurrence of CDI. Conclusion: CDI recurrence rate at VAMC was 14%. No statistically significant association could be made between recurrence of CDI and antibiotic or medication used within 60 days of infection or with chronic disease states at the time of CDI infection. Patients younger than 69.5 years were more likely to continue to have diarrhea after CDI treatment.

Therapy with standard-dose TMP/SMX is associated with a slight increase in the serum potassium concentration. Routine monitoring of the serum potassium concentration in patients who are treated with standard-dose TMP/SMX therapy is unnecessary. However, TMP/SMX should be considered as a possible cause of unexplained hyperkalemia in elderly patients receiving TMP/SMX therapy.

A survey of North Dakota pharmacists was done to determine if significant changes in drug information needs had occurred since an identical survey done 10 years ago. The survey was mailed to 183 practitioners selected at random and a 60% response rate was obtained. There were small but statistically significant increases in the number of questions pharmacists receive and the time spent looking for drug infor mation. However, pharmacists did not use a greater number of books or journals than in 1980. Overall, it appears that North Dakota pharmacists are still under utilized as drug information resources.