A new species of Gesneriaceae, Oreocharis wuxiensis, is described and illustrated from Wuxi County, Chongqing Municipality, China. The new species is morphologically similar to O. giraldii in the leaf blade’s shape and indumentum and the corolla’s shape and color. It can be easily distinguished by the shape of the corolla tube and lobes, the indumentum and pistil length, and the ovary’s size and style. At present, a total of three populations were confirmed in Yintiaoling National Nature Reserve, Wuxi County, with about 500 mature individuals. According to the IUCN Red List Categories and Criteria, it is provisionally assessed as Vulnerable (VU D1).