The solubility data of probenecid in 12 different organic solvents including methanol, methyl acetate, ethanol, ethyl acetate, n-propanol, n-butanol, butyl acetate, n-pentanol, isopropanol, isobutanol, acetone, and methyl tert-butyl ether was measured using the gravimetric method over the temperatures range from 283.15 to 323.15 K at 0.1 MPa. The acetone had much higher solubility to probenecid than to other solvents. Three models, including the modified Apelblat equation, the van’t Hoff model, and the nonrandom two-liquid (NRTL) model, were applied to correlate the measured solubility data. The correlation results were evaluated by the average relative deviation (ARD). All of the ARD values were less than 4.522%, which indicated that the three models have a satisfactory correlation. The thermodynamic properties of mixing of probenecid in 12 pure organic solvents including the enthalpy of mixing, Gibbs energy of mixing, and entropy of mixing were calculated by the NRTL model using the correlation results.

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A new type of device consisting of a lithium niobate film coupled with a distributed Bragg reflector (DBR) was theoretically proposed to explore and release Bloch surface waves for applications in sensing and detection. The film and grating made of lithium niobate (LiNbO3) were placed on both sides of the DBR and a concentrated electromagnetic field was formed at the film layer. By adjusting the spatial incidence angle of the incident light, two detection and analysis modes were obtained, including surface diffraction detection and guided Bloch detection. Surface diffraction detection was used to detect the gas molecule concentrations, while guided Bloch detection was applied for the concentration detection of biomolecule-modulated biological solutions. According to the drift of the Fano curve, the average sensor sensitivities from the analysis of the two modes were 1560 °/RIU and 1161 °/RIU, and the maximum detection sensitivity reached 2320 °/RIU and 2200 °/RIU, respectively. This study revealed the potential application of LiNbO3 as a tunable material when combined with DBR to construct a new type of biosensor, which offered broad application prospects in Bloch surface wave biosensors.