Postoperative radiation and smoking history are associated with late complications. Mini Ti plate should be less used. Patients with risk factors need to be observed for at least 6 to 16 months before further management.
Hydroxyapatite (HA)-coated TiO2 nanotubes (TNTs) have
been reported to enhance osteogenesis. However, the nanoscale topography
of TNTs usually vanishes due to the uncontrollable mineralization
on the surface. In this study, TNTs with different diameters(small,
25 nm; medium, 55 nm; and large, 85 nm) were fabricated by anodization
in 3 different voltages. Enzyme-directed biomineralization was adopted
to deposit calcium phosphate on the above TNTs. The surface structures
and properties of the coatings were characterized by scanning electron
microscopy, dispersive X-ray spectrometry, X-ray diffraction, and
Fourier-transform infrared spectroscopy. The osteogenesis effect of
the hybrid TNT/HA and the original TNTs were evaluated. The results
showed that hydroxyapatite deposited homogeneously along the TiO2 nanotubes while preserving the intrinsic nanotopography.
Mechanically, alkaline phosphatase(ALP) played a critical role in
the mineralization and large nanotube size is more favorable for the
mineralizing process because of more ALP absorption. Besides, the
hybrid nanosurface TNT/HA coating was found to improve the adhesion,
proliferation, and osteogenic differentiation of MC3T3-E1 cells compared
to pure TNTs. Our study suggests that the hybrid TNT/HA coating constructed
by enzyme-directed biomineralization on TiO2 nanotubes
is a promising modification strategy for titanium implants.
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