The construction and therapy strategy of a CTNF-α-exosome-SPION and the preparation of the CTNF-α-exosome-SPION by gene engineering and dehydration synthesis are described here. The CTNF-α-exosome-SPION displays membrane targeting anticancer activity with the help of magnetic force.

With the rapidly development of mobile cloud computing (MCC), the Internet of Things (IoT), and artificial intelligence (AI), user equipment (UEs) are facing explosive growth. In order to effectively solve the problem that UEs may face with insufficient capacity when dealing with computationally intensive and delay sensitive applications, we take Mobile Edge Computing (MEC) of the IoT as the starting point and study the computation offloading strategy of UEs. First, we model the application generated by UEs as a directed acyclic graph (DAG) to achieve fine-grained task offloading scheduling, which makes the parallel processing of tasks possible and speeds up the execution efficiency. Then, we propose a multi-population cooperative elite algorithm (MCE-GA) based on the standard genetic algorithm, which can solve the offloading problem for tasks with dependency in MEC to minimize the execution delay and energy consumption of applications. Experimental results show that MCE-GA has better performance compared to the baseline algorithms. To be specific, the overhead reduction by MCE-GA can be up to 72.4%, 38.6%, and 19.3%, respectively, which proves the effectiveness and reliability of MCE-GA.

Mobile edge computing is an emerging paradigm that supplies computation, storage, and networking resources between end devices and traditional cloud data centers. With increased investment of resources, users demand a higher quality-of-service (QoS). However, it is nontrivial to maintain service performance under the erratic activities of end-users. In this paper, we focus on the service placement problem under the continuous provisioning scenario in mobile edge computing for multiple mobile users. We propose a novel dynamic placement framework based on deep reinforcement learning (DSP-DRL) to optimize the total delay without overwhelming the constraints on physical resources and operational costs. In the learning framework, we propose a new migration conflicting resolution mechanism to avoid the invalid state in the decision module. We first formulate the service placement under the migration confliction into a mixed-integer linear programming (MILP) problem. Then, we propose a new migration conflict resolution mechanism to avoid the invalid state and approximate the policy in the decision modular according to the introduced migration feasibility factor. Extensive evaluations demonstrate that the proposed dynamic service placement framework outperforms baselines in terms of efficiency and overall latency.

No abstract

No abstract