Objective As one of the most common primary headaches in clinical practice, migraine affects the learning ability and life quality of college students worldwide, posing a heavy burden on individuals and society. This study aims to investigate the incidence of migraine among Chinese medical college students and to explore its characteristics and typical triggers. Method From July 2019 to July 2020, North Sichuan Medical College in Sichuan province, China preliminarily screened migraine cases using ID-Migraine through cluster sampling. College students with positive ID-Migraine results would be included in this study if they were further diagnosed with migraine by neurologists based on ICHD-3. After the ethical review, patients’ personal and headache information would be collected, and the frequency, severity, onset time, and related triggers of migraine would be measured. Results The preliminary screening covered 8783 college students. The overall prevalence rate of migraine is 6.57%, 5.90% in men and 6.77% in women. The prevalence rate of migraine is higher for students in the first and second grades (8.01%, 8.05%), and students with a family history of migraine are more likely to suffer from migraine (OR = 1.509, 95% CI 1.060–2.148, P = 0.022 < 0.005). Staying up late (n = 329, 57.01%), stress (n = 319, 55.29%), catch a cold (n = 313, 54.25%) and sleep disorders (n = 302, 52.34%) are the common triggers. Conclusion Migraine is common among college students in North Sichuan Medical College. The incidence is higher among lower grade students, female students, and students with a family history of migraine. Improving sleep quality and reducing stress may be effective in relieving migraines.

Background Menstrual migraine is a particular form of migraine with a significant impact on the quality of life for women afflicted. Presently, no study has reported the quality of life in menstrual migraine patients. This work aims to assess the health-related quality of life and identify its associated factors among Chinese menstrual migraine patients. Methods The cross-sectional study group consisted of 109 patients with menstrual migraine, and the control group consisted of 397 female patients with non-menstrual migraine. In total, 506 patients completed questionnaires for demographic and clinical information, the Self-rating Idea of Suicide Scale, the Hamilton Depression Scale, the Hamilton Anxiety Scale, the Headache Impact Test-6, the Perceived Social Support Scale, the Pittsburgh Sleep Quality Index. Health-related quality of life was measured using the 36-Item Short Form Survey. Results Compared with non-menstrual migraine patients, five dimensions of health-related quality of life were all found to be significantly impaired in menstrual migraine patients. Headache frequency (ß = − 0.218, P = 0.014), the impact of headache on daily life (ß = − 0.270, P = 0.002), depression symptoms (ß = − 0.345, P < 0.001) were significantly associated with physical component summary, depression symptoms (ß = − 0.379, P < 0.001), social support (ß = 0.270, P < 0.001), suicidal ideation (ß = − 0.344, P < 0.001) were closely related to mental component summary. Conclusion Menstrual migraine patients had a significantly poorer health-related quality of life in many domains than non-menstrual migraine patients. Headache frequency, the impact of headache on daily life, depression symptoms, social support, and suicidal ideation were significantly associated with health-related quality of life in menstrual migraine patients. Trial registration: ChiCTR1800014343. This study was registered prospectively on 7 January 2018 at Chinese Clinical Trial registry. http://www.chictr.org.cn/showproj.aspx?proj=24526

Background: Migraineurs are often plagued by sleep disorders. The university student population is high in number and is more vulnerable to migraines. However, no study has analyzed the sleep quality of students with migraine and related contributing factors.Objective: We used the Pittsburgh Sleep Quality Index (PSQI) scale to assess the sleep of migraine patients among college students and to explore the influencing factors of sleep quality.Methods: We performed primary screening for migraine using the ID-migraine screening, and further assessed headache characteristics, sleep, anxiety, depression, and mobile phone addiction in college students with positive primary screening, then diagnosed migraine according to the third edition of the International Classification of Headache Disorders (ICHD-3). Finally, we analyzed the factors influencing sleep quality using Binary Logistic Regression Analysis. Those with scores greater than 5 points on the PSQI scale were believed to have poor sleep quality.Results: The prevalence of migraine was 6.6%. A total of 545 migraineurs were eventually included in the analysis, the incidence of poor sleep quality was 64.04%. The three factors of experiencing aura (OR = 2.966, 95%CI = 1.756–5.010, P &lt; 0.05), anxiety (OR = 2.778, 95%CI = 1.434–5.382, P &lt; 0.05), and high Mobile phone addiction index (MPAI) score (OR = 1.025, 95%CI = 1.002–1.049, P &lt; 0.05) contributed enormously to poor sleep quality. Moreover, the factors of aura symptoms (OR = 3.796, 95%CI = 2.041–7.058, P &lt; 0.05), anxiety (OR = 3.146, 95%CI = 1.473–6.719, P &lt; 0.05), and MPAI score (OR = 1.028, 95%CI = 1.002–1.054, P &lt; 0.05) influenced the sleep quality of female migraineurs rather than male migraineurs.Conclusions: The incidence of poor sleep quality is high among university students with migraine. Aura symptoms, anxiety, and high MPAI score influence the sleep quality of migraineurs, especially females. The proposal of prevention and intervention measures is of great importance to the physical and mental health of students with migraine.Clinical Trial Registration: identifier ChiCTR1800014343.

Background: Menstrual migraine is a special form of migraine with significant impact on quality of life for those women afflicted. Presently, there is no study reported on quality of life in menstrual migraine patients. The study reported here aimed to assess the health-related quality of life and identify its associated factors among Chinese menstrual migraine patients. Methods: The cross-sectional study group consisted of 109 patients with menstrual migraine and the control group consisted of 397 female patients with non-menstrual migraine. In total, 506 patients completed questionnaires for demographic and clinical information, Self-rating Idea of Suicide Scale, Hamilton Depression Scale, Hamilton Anxiety Scale, Headache Impact Test-6, Perceived Social Support Scale, Pittsburgh Sleep Quality Index. Health-related quality of life was measured using the 36-Item Short Form Survey. Results: Compared with non-menstrual migraine patients, five dimensions of health-related quality of life were all found to be significantly impaired in menstrual migraine patients. Headache frequency (ß=-0.218, P=0.014), the impact of headache on daily life (ß=-0.270, P=0.002), depression symptoms (ß=-0.345, P<0.001) were significantly associated with physical component summary, depression symptoms (ß= -0.379, P<0.001), social support (ß=0.270, P<0.001), suicidal ideation (ß=-0.344, P<0.001) were closely related to mental component summary. Conclusion: Menstrual migraine patients had significantly poorer health-related quality of life in many domains than non-menstrual migraine patients. Headache frequency, the impact of headache on daily life, depression symptoms, social support and suicidal ideation were significantly associated with health-related quality of life in menstrual migraine patients.Trial registration: ChiCTR1800014343. Registered 01 July 2018 at Chinese Clinical Trial registry. http://www.chictr.org.cn/showproj.aspx?proj=24526

Background Menstrual migraine is a special form of migraine with significant impact on quality of life for those women afflicted. Presently, there is no study reported on quality of life in menstrual migraine patients. The study reported here aimed to assess the health-related quality of life and identify its associated factors among Chinese menstrual migraine patients. Methods The cross-sectional study group consisted of 109 patients with menstrual migraine and the control group consisted of 397 female patients with non-menstrual migraine. In total, 506 patients completed questionnaires for demographic and clinical information, Self-rating Idea of Suicide Scale, Hamilton Depression Scale, Hamilton Anxiety Scale, Headache Impact Test-6, Perceived Social Support Scale, Pittsburgh Sleep Quality Index. Health-related quality of life was measured using the 36-Item Short Form Survey. Results Compared with non-menstrual migraine patients, five dimensions of health-related quality of life were all found to be significantly impaired in menstrual migraine patients. Headache frequency (ß=-0.218, P=0.014), the impact of headache on daily life (ß=-0.270, P=0.002), depression symptoms (ß=-0.345, P<0.001) were significantly associated with physical component summary, depression symptoms (ß= -0.379, P<0.001), social support (ß=0.270, P<0.001), suicidal ideation (ß=-0.344, P<0.001) were closely related to mental component summary. Conclusion Menstrual migraine patients had significantly poorer health-related quality of life in many domains than non-menstrual migraine patients. Headache frequency, the impact of headache on daily life, depression symptoms, social support and suicidal ideation were significantly associated with health-related quality of life in menstrual migraine patients. Trial registration: ChiCTR1800014343. Registered 01 July 2018 at Chinese Clinical Trial registry. http://www.chictr.org.cns