Objective: The role of VEGF in vascular remodeling of target organs exposed to chronic hypertension is poorly understood. The authors compared capillary density (CD), capillary‐to‐fiber ratio (C/F), and VEGF mRNA expression in the hearts (left ventricle [LV]), and skeletal muscles (soleus and anterior tibialis [AT]) of 18‐week‐old male spontaneously hypertensive rats (SHR) and age‐matched male Wistar‐Kyoto (WKY) and Sprague‐Dawley (SD) rats. Methods: CD or C/F in LV, soleus, and AT of SHR, WKY, and SD rats was determined by analysis of randomly acquired digital images of cryosections stained with FITC‐conjugated GS‐I lectin. VEGF mRNA expressions in the tissues were determined by Northern blot. Results: VEGF mRNA expressions in LV of SHR were 3.84‐ and 5.05‐fold higher, compared to SD and WKY rats, respectively (n = 6; p < .01). There were no significant differences in VEGF mRNA expression in soleus or AT among SHR, WKY, and SD rats (p > .05). CD in LV of SHR (4975 ± 167) was significantly higher than WKY or SD rats, 4151 ± 169 and 3807 ± 187 mm−2, respectively (p < .05). In LV of SHR, C/F increased (35%) more significantly than CD (increased 20%), compared to WKY rats. CD, or C/F in soleus or AT of SHR was similar to that observed in WKY or SD rats. Conclusions: VEGF expression, CD, and C/F in the heart (LV) of SHR are significantly increased, compared to WKY and SD rats. The data are consistent with the possibility that VEGF may contribute to capillary growth as a compensatory response to hypertension.

Objective: This study aims to investigate the risk factors of prelaryngeal lymph node metastasis in papillary thyroid carcinoma and its clinical application value. Methods: The clinical pathological features and metastatic risks were statistically analyzed by reviewing 254 patients with papillary thyroid carcinoma, who received their first operation and prelaryngeal lymph node dissection in our department. Results: The detection of prelaryngeal lymph nodes, tumor size and any paratracheal lymph node metastasis were correlated with the number of paratracheal lymph node metastasis (P<0.05), but these were not correlated with age, gender, multiple foci, tumor size, any paratracheal lymph node metastasis, metastatic location, or foci location (P>0.05). Conclusion: Paratracheal lymph node metastasis indicates a high possibility of prelaryngeal lymph node metastasis. Paratracheal lymph node dissection combined with prelaryngeal lymph node dissection should be simultaneously considered in operations for thyroid papilla carcinoma.

Due to factors such as objective conditions, time, and cost, it is impractical to carry out substantive indoor physical modeling experiments. Numerical simulation, whilst serving oilfield computation, is an economic technology with high speed and repeatability. Based on some typical physical modeling experiments, this paper establishes a numerical simulation model on laboratory units which complies with the experiments. This model aims at fitting displacement experimental dynamics and calibrating parameters in physical modeling experiments. Via this modeling and taking the experiment on profile controlling and flooding with weak gel as an example, computations over several schemes are accomplished, which visually reveal the mechanisms of fluid direction change, oil displacement, and injection profile improvement. The results demonstrate this approach a perfect combination of physical model experiment and numerical simulation, therefore can be widely used in a variety of displacement experiments for oilfield development, to achieve comprehensive studies while saving time and cost.

There are lots of factors effect on weak gel flooding.This paper based on the conceptual model by changing the model parameters and using orthogonal design to analyze the effects of different factors on weak gel flooding. The descending order of influence is slug size, flooding time, oil-water viscosity ratio, permeability range, concentration of polymer, slug combination and polymer-cross linker ratio.