Abstract-A novel compact quadruplexer based on defected stepped impedance resonator (DSIR) with high isolation is presented in this paper. The proposed quadruplexer consists of a common input feeding line, four kinds of folded DSIRs and four individual output feeding lines. Considering the loading effect among channel filters, the input DSIRs must be properly located with respect to the common feeding line in order to realize all external quality factors at the same time, so that the loading effect becomes very small. Furthermore, since the compact DSIRs resonate at multiple fundamental frequencies, a high-isolation quadruplexer with size reduction can be obtained. A fabricated prototype of the proposed quadruplexer is developed. The channel performance obtained by measurement and EM simulation are in good agreement.