Resistive sensor is widely used in every aspect of production and life, and it has many good qualities, like wide resistance range, nonlinear resistance change and so on. Resistance sensor measurement system is an important step of design and improvement of the property of resistive sensor. A reformed resistive sensor measuring system was discussed in this paper, and 52 series single-chip computer control system was used as a key part. Analysis results shows that it can well realize automatic Ω 10-100 m Ω resistance measurements.