SummaryRuditapes philippinarum is an economically important bivalve with remarkable diversity in its shell coloration patterns. In this study, we sequenced the whole genome of the Manila clam and investigated the molecular basis of its adaptation to hypoxia, acidification, and parasite stress with transcriptome sequencing and an RNA sequence analysis of different tissues and developmental stages to clarify these major issues. A number of immune-related gene families are expanded in the R. philippinarum genome, such as TEP, C3, C1qDC, Hsp70, SABL, and lysozyme, which are potentially important for its stress resistance and adaptation to a coastal benthic life. The transcriptome analyses demonstrated the dynamic and orchestrated specific expression of numerous innate immune-related genes in response to experimental challenge with pathogens. These findings suggest that the expansion of immune- and stress-related genes may play vital roles in resistance to adverse environments and has a profound effect on the clam's adaptation to benthic life.

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We propose and demonstrate an optical signal processor performing matrix-vector multiplication, which is composed of laser-modulator array, multiplexer, splitter, microring modulator matrix and photodetector array. 8 × 10⁷ multiplications and accumulations (MACs) per second is implemented at the clock at a clock frequency of 10 MHz. All functional units can be ultimately monolithically integrated on a chip with the development of silicon photonics and an efficient high-performance computing system is expected in the future.

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