Complex biomedical data generated during clinical, omics and mechanism-based experiments have increasingly been exploited through cloud- and visualization-based data mining techniques. However, the scientific community still lacks an easy-to-use web service for the comprehensive visualization of biomedical data, particularly high-quality and publication-ready graphics that allow easy scaling and updatability according to user demands. Therefore, we propose a community-driven modern web service, Hiplot (https://hiplot.org), with concise and top-quality data visualization applications for the life sciences and biomedical fields. This web service permits users to conveniently and interactively complete a few specialized visualization tasks that previously could only be conducted by senior bioinformatics or biostatistics researchers. It covers most of the daily demands of biomedical researchers with its equipped 240+ biomedical data visualization functions, involving basic statistics, multi-omics, regression, clustering, dimensional reduction, meta-analysis, survival analysis, risk modelling, etc. Moreover, to improve the efficiency in use and development of plugins, we introduced some core advantages on the client-/server-side of the website, such as spreadsheet-based data importing, cross-platform command-line controller (Hctl), multi-user plumber workers, JavaScript Object Notation-based plugin system, easy data/parameters, results and errors reproduction and real-time updates mode. Meanwhile, using demo/real data sets and benchmark tests, we explored statistical parameters, cancer genomic landscapes, disease risk factors and the performance of website based on selected native plugins. The statistics of visits and user numbers could further reflect the potential impact of this web service on relevant fields. Thus, researchers devoted to life and data sciences would benefit from this emerging and free web service.

In this study we utilized computational fluid dynamic (CFD) techniques to construct a numerical simulation of nasal cavity airflow pre and post virtual functional endoscopic surgery (FESS). A healthy subject was selected, and CFD techniques were then applied to construct an anatomically and proportionally accurate three-dimensional nasal model based on nasal CT scans. A virtual FESS intervention was performed numerically on the normal nasal model using Fluent software. Navier-Stokes and continuity equations were used to calculate and compare airflow, velocity, distribution and pressure in both the pre and post FESS models. In the post-FESS model, there was an increase in airflow distribution in the maxillary, ethmoid and sphenoid sinuses, and a 13% increase through the area connecting the middle meatus and the surgically opened ethmoid. There was a gradual decrease in nasal resistance in the posterior ethmoid sinus region following FESS. These findings highlight the potential of this technique as a powerful preoperative assessment tool to aid clinical decision-making.

Recent years have witnessed the unprecedented rising of time series from almost all kindes of academic and industrial fields. Various types of deep neural network models have been introduced to time series analysis, but the important frequency information is yet lack of effective modeling. In light of this, in this paper we propose a wavelet-based neural network structure called multilevel Wavelet Decomposition Network (mWDN) for building frequency-aware deep learning models for time series analysis. mWDN preserves the advantage of multilevel discrete wavelet decomposition in frequency learning while enables the fine-tuning of all parameters under a deep neural network framework. Based on mWDN, we further propose two deep learning models called Residual Classification Flow (RCF) and multi-frequecy Long Short-Term Memory (mLSTM) for time series classification and forecasting, respectively. The two models take all or partial mWDN decomposed sub-series in different frequencies as input, and resort to the back propagation algorithm to learn all the parameters globally, which enables seamless embedding of wavelet-based frequency analysis into deep learning frameworks. Extensive experiments on 40 UCR datasets and a real-world user volume dataset demonstrate the excellent performance of our time series models based on mWDN. In particular, we propose an importance analysis method to mWDN based models, which successfully identifies those time-series elements and mWDN layers that are crucially important to time series analysis. This indeed indicates the interpretability advantage of mWDN, and can be viewed as an indepth exploration to interpretable deep learning.