Knowledge of therapeutic targets and early drug candidates is useful for improved drug discovery. In particular, information about target regulators and the patented therapeutic agents facilitates research regarding druggability, systems pharmacology, new trends, molecular landscapes, and the development of drug discovery tools. To complement other databases, we constructed the Therapeutic Target Database (TTD) with expanded information about (i) target-regulating microRNAs and transcription factors, (ii) target-interacting proteins, and (iii) patented agents and their targets (structures and experimental activity values if available), which can be conveniently retrieved and is further enriched with regulatory mechanisms or biochemical classes. We also updated the TTD with the recently released International Classification of Diseases ICD-11 codes and additional sets of successful, clinical trial, and literature-reported targets that emerged since the last update. TTD is accessible at http://bidd.nus.edu.sg/group/ttd/ttd.asp. In case of possible web connectivity issues, two mirror sites of TTD are also constructed (http://db.idrblab.org/ttd/ and http://db.idrblab.net/ttd/).

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Abstract. In this paper we develop a new superfast solver for Toeplitz systems of linear equations. To solve Toeplitz systems many people use displacement equation methods. With displacement structures, Toeplitz matrices can be transformed into Cauchy-like matrices using the FFT or other trigonometric transformations. These Cauchy-like matrices have a special property, that is, their off-diagonal blocks have small numerical ranks. This low-rank property plays a central role in our superfast Toeplitz solver. It enables us to quickly approximate the Cauchy-like matrices by structured matrices called sequentially semiseparable (SSS) matrices. The major work of the constructions of these SSS forms can be done in precomputations (independent of the Toeplitz matrix entries). These SSS representations are compact because of the low-rank property. The SSS Cauchy-like systems can be solved in linear time with linear storage. Excluding precomputations the main operations are the FFT and SSS system solvers, which are both very efficient. Our new Toeplitz solver is stable in practice. Numerical examples are presented to illustrate the efficiency and the practical stability.