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IntroductionAccumulating evidences indicate that microRNA-21(miR-21) show significant high concentration in plasma of gastric cancer (GC) patients compared to normal individuals, suggesting that it may be a useful novel diagnostic biomarker for gastric cancer. Therefore, we aimed to assess the potential diagnostic value of miR-21 for gastric cancer in this study.MethodsLiterature database including PubMed, Embase, the Cochrane Library, Web of Science, Ovid, SciVerse, Science Direct, Scopus, BioMed Central, Biosis previews,Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang DATA were searched for publications concerning the diagnostic value of miR-21 for GC without language restriction. The quality of each study was scored with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS). Then, data were retrieved from any qualified article hits and subject to meta-analysis. Receiver operating characteristic curves (ROC) were used to check the overall test performance. Evidence of heterogeneity was evaluated using the Chi-square and I 2 test.ResultsFive studies with a total 251 GC patients and 184 control individuals were included in this meta-analysis. All of the included studies are of high quality (QUADAS score$13). The summary estimates revealed that the pooled sensitivity is 66.5% (95% confidence interval (CI): 55.0%–76.3%) and the specificity is 83.1% (95% CI: 69.4%–91.5%). In addition, the area under the summary ROC curve (AUC) is 0.80.ConclusionThe current evidence suggests that miR-21 has potential diagnostic value with a moderate sensitivity and specificity for GC. More prospective studies on the diagnostic value of miR-21 for GC are needed in the future.

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Ultrasonic effect in the synthesis of catalysts of NiAl oxides prepared starting from the coprecipitation method of a hydrotalcite structure was evaluated in this work. Removal of carbonyl sulfide (COS) at low temperature over the hydrotalcite-derived oxides was studied. The samples were characterized by X-ray Diffraction (XRD), scanning electron microscope (SEM), N2 adsorption/desorption techniques, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and CO2 temperature-programmed desorption (TPD). It is found that hydrotalcite treated with ultrasonic has smaller average crystallite size and higher particle dispersion compared to hydrotalcite without ultrasonic treatment. As a result, mixed oxides derived from hydrotalcite treated with ultrasonic show more developed pore structure which is good for the physical adsorption of gaseous pollutant. The result of desulfuration test showed that removal efficiency of COS on the NiAl mixed oxides prepared by ultrasonic method (30min) is greater than that on the catalyst prepared without the ultrasonic irradiation assistance with the same aging time. One important reason for the high activity is that when the ultrasonic is used the number of weak basic sites (OH(-) groups) and moderate basic sites (M-O) was increased, whereas the number of strong basic sites (O(2-)) was decreased. Therefore, ultrasonic treatment promoted the COS hydrolysis and suppress the poisoning of the catalyst.