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A rat model of intracranial atherosclerosis was effectively developed by high-cholesterol diet and L-NAME administration. This clinically relevant model would be beneficial for studying ICAS.

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This paper proposes an image textural analytical method for estimating the crowd density and counting. At first, the target detection is conducted to obtain the foreground image. This crowd image is used to calculate the gray level co-occurrence matrix (GLCM). Then, according to the characteristic values of the gray level co-occurrence matrix, i.e., energy, entropy, contrast, homogeneity, we use support vector machine (SVM) to estimate crowd density. Simultaneously, the method of linear regression is used to estimate the crowd counting. The accuracy of evaluation is improved since we extract the target image textural traits to overcome the influence of background for estimation results. Finally, the experimental results show that the proposed approaches of crowd density and counting are feasible and effective.