During the last decade, the problem of suicide has become more serious in individuals with depression. Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). This study aims to investigate the efficacy of magnetic resonance imaging (MRI)‐based neuronavigation‐guided daily high‐dose rTMS for rapidly improving suicidal ideation in treatment‐naive patients with MDD. In the present 1‐week double‐blind study, 42 treatment‐naive patients with MDD with suicidal ideation were randomly assigned to the treatment of escitalopram oxalate tablets (10 mg/d) in combination with either active (n = 21) or sham (n = 21) rTMS. The TMS coil was positioned over a specified target location (−44, 40, and 29) in left dorsolateral prefrontal cortex based on MRI data. The severity of suicidal ideation was measured by the Beck Scale for Suicide Ideation (BSI). The 24‐item Hamilton Depression Rating Scale (HAMD‐24) and Montgomery–Åsberg Depression Rating Scale (MADRS) were utilized to assess the severity of depression. The Wisconsin Card Sorting Test, Continuous Performance Test, and Stroop Color–Word Test were adopted to assess executive function. In contrast to the sham group, the active rTMS group showed a significantly greater BSI score reduction at the third day and the seventh day (P < 0.001). Moreover, the active rTMS group showed a significantly greater HAMD (P < 0.001) and MADRS (P < 0.001) score reduction at the seventh day in comparison to the sham group. The present findings suggested that the neuronavigation‐guided high‐dose rTMS may be a novel method to rapidly reduce suicidal ideation and mitigate depressive symptoms.

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Background Schizophrenia is associated with widespread cognitive impairment. The MATRICS Consensus Cognitive Battery (MCCB) is most frequently used to assess cognitive function. However, the MCCB test is time consuming for the clinician. Virtual reality (VR) has emerged as an adjunctive tool to overcome this limitation and provides a new means to assess cognitive function. Methods The present study examined the validity and safety of using VR technology to assess cognitive function in Han Chinese patients with schizophrenia (SZs). The VR cognition training system (VRCTS) was used to simulate real-life supermarkets and assess cognitive function. Thirty-two SZs and 25 healthy controls (HCs) underwent VRCTS and MCCB assessments. An auxiliary diagnosis model was created based on the outcomes of the VRCTS to classify SZs and HCs by cognitive impairment. Results Significant differences in completion time between the SZs and HCs were detected using the VRCTS. SZs spent more time completing tasks than HCs. The outcome of VRCTS significantly correlated with the MCCB. The auxiliary diagnosis model had a sensitivity of 88.89% and a specificity of 88.89%. Conclusions These results support the use of VR technology in the assessment of cognitive impairment in Han Chinese schizophrenia patients. Trial registration China Clinical Trial Registry, ChiVTR1800016121. Registered 13 May 2018, http://www.chictr.org.cn/showproj.aspx?proj=27233

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The characteristics of the daily behaviors of village residents and their symbiotic relationship with the environment play important roles in optimizing the spatial configuration of villages and promoting the sustainable development of the villages and the environment. This paper used the questionnaire survey method and the field observation method, collected the data of different residents’ activities by interviews and surveys in Meiwu Village, Gannan Prefecture, and analyzed the characteristics of the local residents’ behaviors and activities, as well as their interaction with spaces from the perspective of time. The results showed that the types of daily activities of village residents in alpine pastoral areas can be divided into four types: life type, survival type, leisure type, and folk type, and there were significant differences in the types of daily activities and the corresponding spaces of the different groups. Residents’ daily behaviors determine the choice and construction of the village spaces, and residents lifestyles promote the functional transformation of the living spaces. On the other hand, the village spaces can also affect the behavioral activities. This study is helpful to improve the method of evaluating the daily living spaces of pastoral villages based on residents’ behaviors, and the conclusion of the empirical study has certain guiding significance for the rural planning of alpine pastoral areas under the humanistic concept.