These studies demonstrate that acute administration of nitro-fatty acids is effective to reduce vascular inflammation in vivo. These findings reveal a direct role of nitro-fatty acids in the disruption of the TLR4 signalling complex in lipid rafts, upstream events of the NF-κB pathway, leading to resolution of pro-inflammatory activation of NF-κB in the vasculature.

After completing this course, the reader will be able to:1. Describe the present clinical practice and controversies regarding the use of PORT in resected pIIIA-pN2 NSCLC.2. Evaluate the effect of PORT on overall survival and on tumor control in this subgroup of patients.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTBackground. For patients with resected pathological stage IIIA-N2 non-small cell lung cancer (NSCLC), the role of postoperative radiotherapy (PORT) is not well defined. In this single-institutional study, we re-evaluated the effect of PORT on overall survival (OS) as well as tumor control in this subgroup of patients.

Color Doppler imaging is a reliable method for evaluation of vertebral artery stenosis. The results derived from this study can be used as a reference for establishing sonographic criteria for proximal vertebral artery stenosis.

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