N-glycosylation is one of the most common types of protein modifications and it plays a vital role in normal physiological processes. However, aberrant N-glycan modifications are closely associated with the pathogenesis of diverse diseases, including processes such as malignant transformation and tumor progression. It is known that the N-glycan conformation of the associated glycoproteins is altered during different stages of hepatocarcinogenesis. Characterizing the heterogeneity and biological functions of glycans in liver cancer patients will facilitate a deeper understanding of the molecular mechanisms of liver injury and hepatocarcinogenesis. In this article, we review the role of N-glycosylation in hepatocarcinogenesis, focusing on epithelial-mesenchymal transition, extracellular matrix changes, and tumor microenvironment formation. We highlight the role of N-glycosylation in the pathogenesis of liver cancer and its potential applications in the treatment or diagnosis of liver cancer.

Polysaccharide-based aerogels show great potential in heat absorption, but it lacks comprehensive evaluation system for their endothermic properties. To fully assess their endothermic properties, konjac glucomannan (KGM)/starch aerogel was used and its heat absorption performance (HAP) was investigated. It was found that the heat absorption ability of the samples was attributed to thermal collapse of the samples at high temperature. The composition, structure, size, and mass of aerogels would have effect on their HAP. The cellulose acetate (CA) aerogel showed better HAP than KGM/starch aerogel with the same volume. However, the performance of KGM/starch aerogel excelled CA under the same mass. These results were in accordance with the results obtained by thermal conductivity analyzer, which indicated the potential of the system to evaluate the HAP of the aerogels comprehensively.